Polymyxin B sulfate

Name: Polymyxin B sulfate
SKU: P5747
Availability: InStock

Product ID P5747

Cas No. 1405-20-5

Purity ≥6500 iu/mg

Product Unit Size	Cost	Quantity		Stock

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Description

Polymyxin B is a mixture of polymyxin B1, B2, B3 and B1-1 sulfates; polymyxin B is a cationic lipid oligopeptide derived from Bacillus polymyxa that displays antibacterial activity against all gram-negative bacteria except species of Proteus. Polymyxin B kills both proliferative and quiescent cells in vitro. Polymyxin B inhibits cellular respiration by inhibiting type II NADH-quinone oxidoreductase activity. This compound also induces aggregation of lipopolysaccharide (LPS) in bacterial cell membranes, altering membrane potential and causing leakage of cellular components. Polymyxin B has been used to treat septic shock induced by LPS of gram-negative bacteria, preventing LPS-induced caspase activity, Fas expression, Bax/Bcl-2 ratio alteration, and apoptosis.

Product Info

Cas No.	1405-20-5
Purity	≥6500 iu/mg
Formula	C₅₆H₁₀₀N₁₆O₁₇S
Formula Wt.	1301.6
IUPAC Name	N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9, 18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)- 2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16, 19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1- oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
Synonym	Aerosporin
Solubility	Soluble in water (50 mg/mL, hazy solution).
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	P5747 MSDS PDF
Info Sheet	P5747 Info Sheet PDF

References

Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2013 Oct 30. [Epub ahead of print]. PMID: 24169795.

Zhai B, Lin X. Evaluation of the anticryptococcal activity of the antibiotic polymyxin B in vitro and in vivo. Int J Antimicrob Agents. 2013 Mar;41(3):250-4. PMID: 23313397

Domingues MM, Inácio RG, Raimundo JM, et al. Biophysical characterization of polymyxin B interaction with LPS aggregates and membrane model systems. Biopolymers. 2012;98(4):338-44. PMID: 23193598.

Martin EL, Ranieri VM. Endotoxin removal by polymyxin B immobilized cartridge inactivates circulating proapoptotic factors. Contrib Nephrol. 2010;167:65-76. PMID: 20519900.

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Polymyxin B sulfate

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Description

Product Info

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References

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