• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
PR-619

PR-619

Product ID P7000
Cas No. 2645-32-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $59.30 In stock
5 mg $126.50 In stock
25 mg $295.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PR-619 inhibits deubiquitinating enzymes (DUBs) and is used to study the role of ubiquitination in neurodegenerative diseases. This compound displays anti-inflammatory activity, inhibiting secretion of IL-1β in macrophages. In oligodendrocytes, PR-619 activates autophagy and aggrosome formation, stabilizes the microtubule network, and induces stress responses.

Product Info

Cas No.

2645-32-1

Purity

≥98%

Formula

C7H5N5S2

Formula Wt.

223.27

Chemical Name

2,6-Diamino-3,5-pyridinediyl bis(thiocyanate)

IUPAC Name

2,6-Diamino-3,5-pyridinediyl bis(thiocyanate)

Synonym

2,6-Diamino-3,5-dithiocyanopyridine

Solubility

DMSO 45 mg/mL Water Insoluble Ethanol Insoluble

Appearance

yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P7000 MSDS PDF

Info Sheet

P7000 Info Sheet PDF

References

Zhou Y, Zhao D, Yue R, et al. Inflammasomes-dependent regulation of IL-1β secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages. Antonie Van Leeuwenhoek. 2015 Jul;108(1):163-71. PMID: 25980833.

Seiberlich V, Borchert J, Zhukareva V, et al. Inhibition of protein deubiquitination by PR-619 activates the autophagic pathway in OLN-t40 oligodendroglial cells. Cell Biochem Biophys. 2013 Sep;67(1):149-60. PMID: 23686611.

Seiberlich V, Goldbaum O, Zhukareva V, et al. The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim Biophys Acta. 2012 Nov;1823(11):2057-68. PMID: 22565157.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B177550

    Benzbromarone

    Non-competitive inhibitor of xanthine oxidase.<...

    ≥99%
  • C446176

    Clemastine Fumarate

    Antihistamine with potential neuroprotective ac...

    ≥99%
  • O1176

    n-Octyl Caffeate

    Caffeic acid derivative.

    ≥98%
  • E6232

    (−)-Epicatechin Gallate

    Flavanol originally found in Camilla (green tea...

    ≥98%
  • K0038

    Kahweol Oleate

    Diterpene found in coffee beans.

    ≥98%
  • E846184

    Everolimus EP Impurity B

    Everolimus impurity

    ≥96% (mix of E/Z)
  • H9803

    Hyaluronic Acid Sodium (0.2 -5 kDA)

    Glycosaminoglycan

  • T3099

    Thymus Factor

    Endogenous peptide, involved in immune signalin...

    ≥95%
  • T1849

    Temozolomide

    Imidazotetrazine, DNA alkylator.

    ≥98%
  • H189921

    1,2,3,4,5,6-Hexabromocyclohexane

    JAK2 inhibitor

    ≥98%
  • L3374

    Lisinopril Dihydrate

    Enalapril analog; ACE inhibitor.

    ≥98%
  • D324096

    Diclofenac Impurity B

    Impurity of diclofenac

    ≥98%
  • M1876

    16-O-Methylcafestol

    Diterpene cafestol derivative found in coffee b...

    ≥98%
  • L8262

    Lupinine

    Alkaloid found in species of Loranthus, Calia, ...

    ≥98%
  • G3254

    10-Gingerol

    Phenol found in Zingiber; 5-HT3 antagonist.

    ≥99%
  • C9670

    Cyromazine

    Triazine, melamine derivative, insect growth re...

    ≥98%
  • A4777

    Altiratinib

    c-MET, Tie-2, VEGFR inhibitor.

    ≥98%
  • A2244

    Aflatoxicol

    Mycotoxin, metabolite of aflatoxin B1 produced ...

    ≥98%
  • D3331

    α,β-Dihydroresveratrol

    Polyphenol found in various plant sources, resv...

    ≥99%
  • H8162

    (−)-Huperzine A

    Sesquiterpene alkaloid found in Huperzia serrat...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only