Prednisone

Name: Prednisone
SKU: P7020
Availability: InStock

Product ID P7020

Cas No. 53-03-2

Purity ≥98%

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Description

Prednisone is a synthetic corticosteroid/glucocorticoid that exhibits no biological activity until converted to its active metabolite, prednisolone. Once converted, this compound exhibits anti-inflammatory, immunosuppressive, anti-allergic, neuroprotective, and anticancer chemotherapeutic activities. Prednisone is one component of the CHOP chemotherapeutic cocktail that is clinically used to treat leukemias and lymphomas; in animal models of subarachnoid hemorrhage, CHOP inhibits neuronal apoptosis. Prednisone also inhibits expression of IL-6 and is clinically used to treat rheumatoid arthritis.

Product Info

Cas No.	53-03-2
Purity	≥98%
Formula	C₂₁H₂₆O₅
Formula Wt.	358.43
Chemical Name	17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
IUPAC Name	(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10, 13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3, 11-dione
Synonym	Ancortone, Colisone, Decortin, Hostacortine, Orasone, Paracort, Sone, Ultracorten
Melting Point	233-235°C (dec)
Solubility	Slightly soluble in water and ethanol (6.5 mg/mL).
Appearance	White to practically white, odorless crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	P7020 MSDS PDF
Info Sheet	P7020 Info Sheet PDF

References

Hoy SM. Bendamustine: a review of its use in the management of chronic lymphocytic leukaemia, rituximab-refractory indolent non-Hodgkin's lymphoma and multiple myeloma. Drugs. 2012 Oct 1;72(14):1929-50. PMID: 22950536.

Clarke L, Kirwan J. Efficacy, safety and mechanism of action of modified-release prednisone in rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2012 Jun;4(3):159-66. PMID: 22850902.

He Z, Ostrowski RP, Sun X, et al. CHOP silencing reduces acute brain injury in the rat model of subarachnoid hemorrhage. Stroke. 2012 Feb;43(2):484-90. PMID: 22180248.

Manns MP, Strassburg CP. Therapeutic strategies for autoimmune hepatitis. Dig Dis. 2011;29(4):411-5. PMID: 21894012.

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Prednisone

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