LKT Labs

Biochemicals for Life Science Research

Progesterone

Progesterone

Product ID P6854
Cas No. 57-83-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $43.40 In stock
25 g $126.30 In stock
100 g $457.90 In stock
Bulk Quote

Quicklinks

Description

Progesterone is an endogenous steroid hormone that activates progesterone receptors (PRs) and inhibits mineralocorticoid receptors (MRs), nicotinic acetylcholine receptors (nAChRs), and σ1/2 receptors. Progesterone exhibits neuroprotective activity, inducing myelin sheath formation and supporting neurotransmission. Progesterone also plays a significant role in reproduction and mammary gland development. Clinically, this compound is used to prevent preterm birth and is occasionally used in hormone replacement therapy (HRT).

Product Info

Cas No.

57-83-0
Purity

≥98%
Formula

C21H30O2
Formula Wt.

314.47
Chemical Name

Pregn-4-ene-3,20-dione
IUPAC Name

(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14, 15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Synonym

Corlutin, Gesterol, Luteol, Prolutone, Prolidon, Syngesterone, Utrogestan
Melting Point

128-132°C
Solubility

Insoluble in water. Soluble in alcohol, acetone or dioxane.
Appearance

White or almost white crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P6854 MSDS PDF
Info Sheet

P6854 Info Sheet PDF

References

Johannessen M, Fontanilla D, Mavlyutov T, et al. Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels. Am J Physiol Cell Physiol. 2011 Feb;300(2):C328-37. Erratum in: Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C997. PMID: 21084640.

da Fonseca EB, Bittar RE, Carvalho MH, et al. Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study. Am J Obstet Gynecol. 2003 Feb;188(2):419-24. PMID: 12592250.

Baulieu E, Schumacher M. Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination. Steroids. 2000 Oct-Nov;65(10-11):605-12. PMID: 11108866.

Rupprecht R, Reul JM, van Steensel B, et al. Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur J Pharmacol. 1993 Oct 15;247(2):145-54. PMID: 8282004.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H6225

    HPGDS-inhibitor-1

    HPGDS inhibitor.

    ≥98%
  • T7156

    Tropisetron Hydrochloride

    α7 nAChR partial agonist, 5-HT3 antagonist.

    ≥98%
  • E6880

    Erucin

    Isothiocyanate found in cruciferous vegetables,...

    ≥98%
  • G4481

    Glucagon-like Peptide I Amide (7-36), human

    Endogenous peptide hormone, GLP-1 fragment, inv...

    ≥95%
  • G3554

    Ginsenoside Rb3

    Triterpene saponin found in species of Panax.

    ≥98%
  • N4974

    NMS-E628

    ALK and Ros1 inhibitor, Trk antagonist.

    ≥98%
  • D0368

    2-Epi-16-deoxysarcophine

    Cembranoid found in Sarcophyton.

    ≥98%
  • C179604

    CEP-28122 Mesylate

    ALK inhibitor.

    ≥98%
  • A5235

    Amitriptyline Hydrochloride

    FIASMA, σ1, RyR2, TrkA/B agonist; SERT, NET in...

    ≥98%
  • V0245

    Valdecoxib

    NSAID; CB1 agonist, COX-2 inhibitor.

    ≥98%
  • M0374

    Masitinib

    PDGFR and c-Kit inhibitor.

    ≥99%
  • O1178

    n-Octyl-3-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥98%
  • A4443

    L-(+)-Alliin

    Optically active cysteine derivative found in A...

    ≥98%
  • H9862

    Hypothemycin

    Polyketide found in Setophoma.

    ≥96%
  • A4933

    Amifostine Trihydrate

    Thiol prodrug, antioxidant.

    ≥98%
  • D3210

    Diclofenac free acid

    Somewhat selective in inhibiting COX-2 over COX...

    ≥99%
  • I6933

    Irinotecan Hydrochloride Trihydrate

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • P2304

    Phalloidin

    Phallotoxin found in Amanita phalloides; microt...

    ≥90%
  • C104761

    CCT-196969

    pan-Raf inhibitor.

    ≥98%
  • T3200

    Ticagrelor

    Nucleoside (adenosine) analog; P2Y12 antagonist...

    ≥98%