• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Propafenone Hydrochloride

Propafenone Hydrochloride

Product ID P6852
Cas No. 34183-22-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $51.90 In stock
5 g $145.80 In stock
25 g $377.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Propafenone is a class Ic anti-arrhythmic compound that inhibits β-adrenergic receptors, slows Na+ and Ca2+ influx, and decreases overall cellular excitability. Propafenone inhibits Kv1.4 K+ channels and human cardiac two pore-domain (K2P2) K+ channels. Additionally, propafenone inhibits expression of tyrosinase, TRP-1, and TRP-2 and decreases production of cAMP, suppressing melanogenesis in vitro.

Product Info

Cas No.

34183-22-7

Purity

≥98%

Formula

C21H27NO3 • HCl

Formula Wt.

377.91

Chemical Name

1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3- phenyl-1propanone hydrochloride

IUPAC Name

1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one; hydrochloride

Synonym

Arythmol, Pronon, Rythmol, Rytmonorm

Melting Point

171-174°C

Solubility

Soluble in basic lower aliphatic alcohols, chloroform and hot water. Slightly soluble in cold water. Insoluble in ether.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P6852 MSDS PDF

Info Sheet

P6852 Info Sheet PDF

References

Schmidt C, Wiedmann F, Schweizer PA, et al. Class I antiarrhythmic drugs inhibit human cardiac two-pore-domain K(+) (K2P2) channels. Eur J Pharmacol. 2013 Dec 5;721(1-3):237-48. PMID: 24070813.

Huh S, Jung E, Lee J, et al. Mechanisms of melanogenesis inhibition by propafenone. Arch Dermatol Res. 2010 Sep;302(7):561-5. PMID: 20549222.

Tian L, Jiang X, Rasmusson R, et al. Effect of propafenone on Kv1.4 inactivation. J Physiol Biochem. 2006 Dec;62(4):263-70. PMID: 17615952.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H3278

    HIV Reverse Transcriptase A2.1 Peptide

    Peptide, HIV-1 RT A2.1 epitope.

    ≥95%
  • C6132

    CPI-203

    Triazolothienodiazepine, JQ-1 derivative; BRD i...

    ≥98%
  • M1678

    2-Methoxyestradiol

    Estradiol metabolite; microtubule depolymerizat...

    ≥98%
  • L9874

    L-(+)-Lysine Monohydrate

    Non-endogenous essential amino acid found in me...

    ≥95%
  • S760004

    Stachybotrylactam

    Spirodihydrobenzofuranlactam

    ≥98%
  • G720009

    GS-9901

    Selective inhibitor of the delta isoform of PI3...

    ≥99%
  • H9718

    2-Hydroxyflutamide

    Non-steroid; AR antagonist.

    ≥98%
  • R0020

    RAF265

    B-Raf, VEGFR2, c-Raf, PDGFR, CSF-1R, RET, c-Kit...

    ≥98%
  • S8098

    SU-1498

    Tyrphostin; VEGFR inhibitor.

    ≥99%
  • O4102

    Okadaic Acid Ammonium

    Shellfish toxin produced by dinoflagellates and...

    ≥98%
  • A491337

    9-Aminocamptothecin Hydrochloride

    Derivative of camptothecin.

    ≥98%
  • A044176

    Abemaciclib

    CDK inhibitor.

    ≥98%
  • C5771

    Corticosterone

    Endogenous steroid hormone involved in immune r...

    ≥98%
  • H9613

    N-(4-Hydroxyphenyl)retinamide

    Retinol (vitamin A) analog, binds RBP4; Des1 in...

    ≥98%
  • C0273

    Casin

    Cdc42 GTPase inhibitor.

    ≥97%
  • H1672

    Hesperetin

    Flavanone found in species of Citrus; L-type Ca...

    ≥97%
  • Z3444

    Zileuton

    5-Lipoxygenase inhibitor.

    ≥98%
  • M0273

    Mastoparan 8

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • V0146

    Valsartan

    AT1 inhibitor.

    ≥98%
  • D3301

    Diaveridine

    Coccidiostat; dihydrofolate reductase inhibitor...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only