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Propafenone Hydrochloride

Propafenone Hydrochloride

Product ID P6852
Cas No. 34183-22-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $51.90 In stock
5 g $145.80 In stock
25 g $377.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Propafenone is a class Ic anti-arrhythmic compound that inhibits β-adrenergic receptors, slows Na+ and Ca2+ influx, and decreases overall cellular excitability. Propafenone inhibits Kv1.4 K+ channels and human cardiac two pore-domain (K2P2) K+ channels. Additionally, propafenone inhibits expression of tyrosinase, TRP-1, and TRP-2 and decreases production of cAMP, suppressing melanogenesis in vitro.

Product Info

Cas No.

34183-22-7

Purity

≥98%

Formula

C21H27NO3 • HCl

Formula Wt.

377.91

Chemical Name

1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3- phenyl-1propanone hydrochloride

IUPAC Name

1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one; hydrochloride

Synonym

Arythmol, Pronon, Rythmol, Rytmonorm

Melting Point

171-174°C

Solubility

Soluble in basic lower aliphatic alcohols, chloroform and hot water. Slightly soluble in cold water. Insoluble in ether.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P6852 MSDS PDF

Info Sheet

P6852 Info Sheet PDF

References

Schmidt C, Wiedmann F, Schweizer PA, et al. Class I antiarrhythmic drugs inhibit human cardiac two-pore-domain K(+) (K2P2) channels. Eur J Pharmacol. 2013 Dec 5;721(1-3):237-48. PMID: 24070813.

Huh S, Jung E, Lee J, et al. Mechanisms of melanogenesis inhibition by propafenone. Arch Dermatol Res. 2010 Sep;302(7):561-5. PMID: 20549222.

Tian L, Jiang X, Rasmusson R, et al. Effect of propafenone on Kv1.4 inactivation. J Physiol Biochem. 2006 Dec;62(4):263-70. PMID: 17615952.

Custom Order

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