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Protocatechuic Acid Ethyl Ester

Protocatechuic Acid Ethyl Ester

Product ID P7060
Cas No. 3943-89-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $53.60 In stock
25 g $160.40 In stock
100 g $321.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Protocatechuic acid is a dihydroxyphenolic acid originally found in cruciferous vegetables, sunflowers, rice, and other plants. Protocatechuic acid exhibits a wide variety of beneficial properties, including antioxidative, anti-inflammatory, anti-parasitic, antibacterial, anti-metastatic, and anticancer activities. Protocatechuic acid inhibits TNF-induced expression and release of adhesion molecules and pro-inflammatory cytokines as well as ADP-induced expression of platelet P-selectin. This compound increases quinone reductase activity and acts as a radical scavenger as well. Additionally, protocatechuic acid improves pathology, motor function, and cognition and decreases infarct size in animal models of bilateral common carotid artery occlusion. This compound is active against both gram positive and gram negative bacteria and exerts antiparasitic activity in vitro and in vivo, indicating potential benefit as an antimalarial treatment. In vitro, protocatechuic acid inhibits RhoB activation, decreasing expression of matrix metalloproteinase 2 (MMP2) and inactivating NF-κB and also inhibits human topoisomerase II; these activities result in inhibition of metastasis, invasion, and proliferation in a variety of cellular models.

Product Info

Cas No.

3943-89-3

Purity

≥98%

Formula

C9H10O4

Formula Wt.

182.17

Chemical Name

3,4-Dihydroxybenzoic acid ethyl ester

IUPAC Name

ethyl 3,4-dihydroxybenzoate

Synonym

Ethyl 3,4-dihydroxybenzoate

Melting Point

131-136°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P7060 MSDS PDF

Info Sheet

P7060 Info Sheet PDF

References

Stumpf C, Fan Q, Hintermann C, et al. Anti-inflammatory effects of danshen on human vascular endothelial cells in culture. Am J Chin Med. 2013;41(5):1065-77. PMID: 24117069.

Garcia-Alvarez MC, Moussa I, Njomnang Soh P, et al. Both plants Sebastiania chamaelea from Niger and Chrozophora senegalensis from Senegal used in African traditional medicine in malaria treatment share a same active principle. J Ethnopharmacol. 2013 Oct 7;149(3):676-84. PMID: 23906782.

Kuriyama I, Nakajima Y, Nishida H, et al. Inhibitory effects of low molecular weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation. Mol Med Rep. 2013 Aug;8(2):535-42. PMID: 23799608.

Muley MM, Thakare VN, Patil RR, et al. Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model. Life Sci. 2013 Jul 19;93(1):51-7. PMID: 23743171.

Stojković DS, Zivković J, Soković M, et al. Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system. Food Chem Toxicol. 2013 May;55:209-13. PMID: 23333716.

Li J, Deng Y, Yuan C, et al. Antioxidant and quinone reductase-inducing constituents of black chokeberry (Aronia melanocarpa) fruits. J Agric Food Chem. 2012 Nov 21;60(46):11551-9. PMID: 23131110.

Lin HH, Chen JH, Chou FP, et al. Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activation. Br J Pharmacol. 2011 Jan;162(1):237-54. PMID: 20840540.

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