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Raloxifene Hydrochloride

Raloxifene Hydrochloride

Product ID R0243
Cas No. 82640-04-8
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $90.50 In stock
250 mg $172.20 In stock
500 mg $267.50 In stock
1 g $477.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits agonist activity in bone and antagonist activity in uterine and breast tissues. Raloxifene is clinically used to prevent osteoporosis in post-menopausal women and to treat ER+ breast cancer. This compound exhibits anti-osteoporotic, anti-parasitic, neuromodulatory, and anticancer chemotherapeutic activities. Raloxifene decreases fracture risk and enhances bone strength in clinical settings. In vitro and in vivo, raloxifene inhibits growth of Leishmania and parasitic burden. Additionally, raloxifene increases uptake of glutamate and expression of GLT-1 in astrocytes. In animal models of breast cancer, this compound decreases expression of EGFR, vascular density, and tumor growth.

Product Info

Cas No.

82640-04-8

Purity

≥98%

Formula

C28H27NO4S • HCl

Formula Wt.

510.05

Chemical Name

[6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]- [4-[ 2-(1-piperidinyl) ethoxy] phenyl]methanone hydrochloride

IUPAC Name

[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1- ylethoxy)phenyl]methanone;hydrochloride

Synonym

Evista

Melting Point

258°C

Solubility

Very slightly soluble in water. Soluble in DMSO at 28 mg/mL.

Appearance

Yellowish Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R0243 MSDS PDF

Info Sheet

R0243 Info Sheet PDF

References

Karki P, Webb A, Zerguine A, et al. Mechanism of raloxifene-induced upregulation of glutamate transporters in rat primary astrocytes. Glia. 2014 Aug;62(8):1270-83. PMID: 24782323.

Reimão JQ, Miguel DC, Taniwaki NN, et al. Antileishmanial activity of the estrogen receptor modulator raloxifene. PLoS Negl Trop Dis. 2014 May 8;8(5):e2842. PMID: 24810565.

Gallant MA, Brown DM, Hammond M, et al. Bone cell-independent benefits of raloxifene on the skeleton: a novel mechanism for improving bone material properties. Bone. 2014 Apr;61:191-200. PMID: 24468719.

Taurin S, Allen KM, Scandlyn MJ, et al. Raloxifene reduces triple-negative breast cancer tumor growth and decreases EGFR expression. Int J Oncol. 2013 Sep;43(3):785-92. PMID: 23842642.

Gizzo S, Saccardi C, Patrelli TS, et al. Update on raloxifene: mechanism of action, clinical efficacy, adverse effects, and contraindications. Obstet Gynecol Surv. 2013 Jun;68(6):467-81. PMID: 23942473.

Custom Order

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