Rasagiline Mesylate

Name: Rasagiline Mesylate
SKU: R0272
Availability: InStock

Product ID R0272

Cas No. 161735-79-1

Purity ≥98%

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Description

Rasagiline is an inhibitor of monoamine oxidase B (MAO-B) that is used to treat Parkinson’s disease. Rasagiline may also exhibit effects on MAO-A, as actions on that enzyme are likely responsible for the ability of rasagiline to increase levels of Bcl-2, glial cell line-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF). Rasagiline also displays neuroprotective activity, inhibiting mitochondrial membrane permeability, preventing caspase- and mitochondria-mediated apoptosis.

Product Info

Cas No.	161735-79-1
Purity	≥98%
Formula	C₁₂H₁₃N • CH₃SO₃H
Formula Wt.	267.34
Chemical Name	(R)-N-2-Propynyl-1-indanamine mesylate
IUPAC Name	(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
Melting Point	154.1~155.5°C
Solubility	Freely soluble in water, methanol and ethanol.
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	R0272 MSDS PDF
Info Sheet	R0272 Info Sheet PDF

References

Naoi M, Maruyama W, Inaba-Hasegawa K. Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms. Expert Rev Neurother. 2013 Jun;13(6):671-84. PMID: 23739004.

Naoi M, Maruyama W, Yi H. Rasagiline prevents apoptosis induced by PK11195, a ligand of the outer membrane translocator protein (18 kDa), in SH-SY5Y cells through suppression of cytochrome c release from mitochondria. J Neural Transm. 2013 Nov;120(11):1539-51. PMID: 23681678.

Inaba-Hasegawa K, Akao Y, Maruyama W, et al. Type A monoamine oxidase is associated with induction of neuroprotective Bcl-2 by rasagiline, an inhibitor of type B monoamine oxidase. J Neural Transm. 2012 Apr;119(4):405-14. PMID: 22065207.

Weinreb O, Amit T, Bar-Am O, et al. Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy. Ann N Y Acad Sci. 2007 Dec;1122:155-68. PMID: 18077571.

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Rasagiline Mesylate

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