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Rebamipide is a quinolone derivative that is clinically used for mucosal protection in the treatment of gastritis and ulcers. Rebamipide exhibits antioxidative activity as a radical scavenger and inhibits NSAID-induced lipid peroxidation, alterations in mitochondrial membrane potential, and apoptosis in epithelial cells.
| Cas No. | 90098-04-7 |
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| Purity | ≥98% |
| Formula | C19H15ClN2O4 |
| Formula Wt. | 370.79 |
| Chemical Name | α-[(4-Chlorobenzoyl)-amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid |
| IUPAC Name | 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid |
| Synonym | Proamipide, OPC-12759, Mucosta |
| Melting Point | 288-290°C(dec) |
| Solubility | Soluble in dimethyl- formamide, DMSO (74mg/mL). Slightly soluble in water, methanol and ethanol. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
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| Info Sheet |
Nagano Y, Matsui H, Muramatsu M, et al. Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells. Dig Dis Sci. 2005 Oct;50 Suppl 1:S76-83. PMID: 16184425.
Arakawa T, Kobayashi K, Yoshikawa T, et al. Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing. Dig Dis Sci. 1998 Sep;43(9 Suppl):5S-13S. PMID: 9753220.
Arakawa T, Watanabe T, Fukuda T, et al. Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine. Dig Dis Sci. 1995 Nov;40(11):2469-72. PMID: 7587834.