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Rifapentine is an antibiotic shown to reduce infection and prevent reactivation of tuberculosis in infected macaques. A mouse model showed improved survival rate, alleviated clinical signs, reduced viral load, and reduced injury in target organs when treated with rifapentine.
| Cas No. | 61379-65-5 |
|---|---|
| Purity | ≥97% |
| Formula | C47H64N4O12 |
| Formula Wt. | 877.05 |
| IUPAC Name | [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-[(E)-(4-cyclopentylpiperazin-1-yl)iminomethyl]-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate |
| Synonym | Rifapentin, Cyclopentylrafampicin |
| Solubility | Soluble in MeOH, EtOH, Chloroform, acetone. |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| Info Sheet |
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Sharan R, Ganatra S, Singh D, et al. Isoniazid and rifapentine treatment effectively reduces persistant M. tuberculosis infection in macaque lungs. J Clin Invest. 2022 Sep 15;132(18):e161564. PMID: 35862216
Qian X, Wu B, Tang H, et al. Rifapentine is an entry and replication inhibitor against yellow fever virus both in vitro and in vivo. Emerg Microbes Infect. 2022 Dec;11(1):873-884. PMID: 35249454
Saini V, Ammerman N, Chang Y, et al. Treatment-shortening effect of a novel regimen combining clofazimine and high-dose rifapentine in pathologically distinct mouse models of tuberculosis. Antimicrob Agents Chemother. 2019 May 24;63(6):e00388-19. PMID: 30936097