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RKI-1447 is an inhibitor of ROCK1/2 that exhibits anticancer chemotherapeutic activity. RKI-1447 also displays anti-metastatic potential, suppressing phosphorylation of MLC-2, MYPT-1, inhibiting formation of actin stress fibers, and preventing migration, invasion, and growth of breast cancer cells and tumors.
| Cas No. | 1342278-01-6 |
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| Purity | ≥98% |
| Formula | C16H14N4O2S |
| Formula Wt. | 326.37 |
| Chemical Name | 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea |
| IUPAC Name | 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea |
| Synonym | RKI1447; 1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea; 1-[(3-Hydroxyphenyl)methyl]-3-(4-Pyridin-4-Yl-1,3-Thiazol-2-Yl)urea |
| Solubility | DMSO 65 mg/mL (199.16 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Patel RA, Forinash KD, Pireddu R, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72(19):5025-34. PMID: 22846914.