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Rofecoxib

Rofecoxib

Product ID R5722
Cas No. 162011-90-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $102.00 In stock
250 mg $204.30 In stock
1 g $459.60 In stock
5 g $1,021.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2; it exhibits anti-inflammatory, analgesic, antiepileptic/anticonvulsant, and chemopreventive activities but is no longer clinically administered. Rofecoxib inhibits the formation of bladder tumors in FHIT models of bladder cancer carcinogenesis. Additionally, rofecoxib increases seizure threshold in an adenosine-dependent manner in vivo.

Product Info

Cas No.

162011-90-7

Purity

≥98%

Formula

C17H14O4S

Formula Wt.

314.36

Chemical Name

4-[4-(Methylsulfonyl)-phenyl]-3-phenyl-2(5H)- furanone

IUPAC Name

3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one

Synonym

Vioxx

Melting Point

207-208°C

Solubility

Slightly soluble in methanol and acetone. Insoluble in water.

Appearance

Slightly yellowish powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R5722 MSDS PDF

Info Sheet

R5722 Info Sheet PDF

References

D'Arca D, LeNoir J, Wildemore B, et al. Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor. Urol Oncol. 2010 Mar-Apr;28(2):189-94. PMID: 19372053.

Akula KK, Dhir A, Kulkarni SK. Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism. Epilepsy Res. 2008 Jan;78(1):60-70. PMID: 18054463.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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