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Roxatidine is an antihistamine compound that inhibits H2 histamine receptors, exhibiting antacid and anti-ulcerative activities by preventing gastric acid secretion. Roxatidine also inhibits indomethacin-induced small intestinal injury by increasing mucus secretion in a NO-dependent manner.
| Cas No. | 93793-83-0 |
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| Purity | ≥98% |
| Formula | C19H28N2O4 • HCl |
| Formula Wt. | 384.90 |
| Chemical Name | 2-Acetoxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]- propyl]acetamide hydrochloride |
| IUPAC Name | [2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate;hydrochloride |
| Synonym | Pifatidine, Altat, Gastralgin, Roxit |
| Melting Point | 146-148°C |
| Appearance | White to off-white crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Umegaki E, Yoda Y, Tokioka S, et al. Protective effect of roxatidine against indomethacin-induced small intestinal mucosal injury in rats. J Gastroenterol Hepatol. 2010 May;25 Suppl 1:S35-40. PMID: 20586863.
Murdoch D, McTavish D. Roxatidine acetate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders. Drugs. 1991 Aug;42(2):240-60. PMID: 1717223.