• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
S-Equol

S-Equol

Product ID E6782
Cas No. 531-95-3
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $85.90 In stock
25 mg $321.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

(S)-Equol is a metabolite produced in humans and animals after consuming daidzein, a soy isoflavone. While equol exists in two enantiomeric forms S-equol and R-equol, it is the former that binds preferentially to the estrogen receptor beta. Equol exhibits anti-aging, antioxidative, estrogenic, anti-inflammatory, and chemopreventive activities. In vitro, equol increases expression of extracellular matrix proteins collagen and elastin as well as nerve growth factor (NGF) and decreases expression of aging genes and pro-inflammatory cytokines such as matrix metalloproteinases 1, 3, and 9 (MMP1/3/9), COX-1, IL-6, and IL-1α. In fibroblasts, equol inhibited ROS generation and oxidative stress. In animal models, equol increases activity of catalase, superoxide dismutase (SOD), glutathione peroxidase, and glutathione reductase. Additionally, equol inhibits TNF-α production, NF-κB activation, and IκB kinase degradation in macrophages. This compound increases activation of p53, caspase 3, and poly(ADP)-ribose polymerase (PARP), increases expression of p21 and Bax, and decreases expression of Bcl-2, resulting in apoptosis and inhibition of tumor formation in animal models.

Product Info

Cas No.

531-95-3

Purity

≥99%

Formula

C15H14O3

Formula Wt.

242.27

Chemical Name

(S)-3-(4-Hydroxyphenyl)chroman-7-ol

IUPAC Name

(3S)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol

Synonym

(3S)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol, (S)-(–)-4′,7-isoflavandiol, (S)-Equol, Equol

Melting Point

189.5°C

Solubility

Soluble in DMSO, ethanol, dilute aqueous base. Insoluble in water.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E6782 MSDS PDF

Info Sheet

E6782 Info Sheet PDF

References

Lephart ED. Protective effects of equol and their polyphenolic isomers against dermal aging: microarray/protein evidence with clinical implications and unique delivery into human skin. Pharm Biol. 2013 Nov;51(11):1393-400. PMID: 23862588.

Richardson TE, Simpkins JW. R- and S-equol have equivalent cytoprotective effects in Friedreich's ataxia. BMC Pharmacol Toxicol. 2012 Oct 22;13:12. PMID: 23088310.

Choi EJ, Kim GH. Anticancer mechanism of equol in 7,12-dimethylbenz(a)anthracene-treated animals. Int J Oncol. 2011 Sep;39(3):747-54. PMID: 21667019.

Muñoz Y, Garrido A, Valladares L. Equol is more active than soy isoflavone itself to compete for binding to thromboxane A(2) receptor in human platelets. Thromb Res. 2009 Mar;123(5):740-4. PMID: 18786699.

Kang JS, Yoon YD, Han MH, et al. Estrogen receptor-independent inhibition of tumor necrosis factor-alpha gene expression by phytoestrogen equol is mediated by blocking nuclear factor-kappaB activation in mouse macrophages. Biochem Pharmacol. 2005 Dec 19;71(1-2):136-43. PMID: 16288994.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P3563

    Piperlonguminine

    Found in Piper longum.

    ≥99%
  • A0102

    A23187 Ca-Mg

    Ca2+ ionophore.

    ≥98%, TLC
  • P1869

    Perindopril Erbumine

    ACE inhibitor.

    ≥95%
  • C1600

    Carcinoembryonic Antigen (605-613)

    Carcinoembryonic antigen epitope.

    ≥95%
  • P3210

    Picoplatin

    Pt-based DNA cross-linker.

    ≥98%
  • A6818

    Arenobufagin

    Bufanolide steroid found in Bufo arenarum;VEGFR...

    ≥98%
  • G733409

    GSK-2982772

    RIP1 inhibitor.

    ≥98%
  • L9701

    LY-450139

    GHS-R1a agonist, γ-secretase inhibitor.

    ≥98%
  • I8618

    Ivermectin

    Avermectin; glu-gated Cl- channel activator, Gl...

    ≥95%
  • I4802

    Imatinib Mesylate

    Abl, c-Kit, PDGFR inhibitor.

    ≥98%
  • U682042

    URB602

    Inhibitor of Monoacyglycerol lipase (MAGL).

    ≥98%
  • C9612

    Cyclosporin C

    Cyclosporin metabolite; weak calmodulin inhibit...

    ≥98%
  • S3346

    Silodosin

    α1A-adrenergic antagonist.

    ≥98%
  • I5215

    Indolicidin

    Antimicrobial peptide.

    ≥95%
  • E6397

    EPZ6438

    Potent and selective inhibitor

    ≥98%
  • H5654

    Honokiol

    Lignan found in species of Magnolia; GABA-A pot...

    ≥99%
  • N5770

    Norfloxacin Hydrochloride

    First generation fluoroquinolone antibiotic.

    ≥98%
  • P0049

    Pamidronate Disodium Pentahydrate

    Bisphosphonate.

    ≥98%
  • I0502

    Ibandronate Sodium Monohydrate

    Bisphosphonate.

    ≥98%
  • A9435

    Axitinib

    VEGFR inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only