LKT Labs

Biochemicals for Life Science Research

[Sar1 Ile8]-Angiotensin II

[Sar1 Ile8]-Angiotensin II

Product ID A5282
Cas No. 67724-27-0
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $81.70 In stock
10 mg $138.90 Please Inquire
25 mg $245.30 Please Inquire
Bulk Quote

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Description

Angiotensin II (AT II) is a peptide produced from AT I by angiotensin-converting-enzyme (ACE). AT II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels; this results in contraction and vasoconstriction, increasing blood pressure. AT II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney. Here, AT II increases reabsorption of Na+ and HCO3- and excretion of H+, increasing blood volume and pH and further increasing blood pressure.

Product Info

Cas No.

67724-27-0
Purity

≥95%
Formula

C46H74N13O10
Formula Wt.

968.1
IUPAC Name

2-[[1-[2-[[2-[[2-[[2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino) acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4- hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol- 5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid
Solubility

Soluble in water.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A5282 MSDS PDF
Info Sheet

A5282 Info Sheet PDF

References

De Giusti VC, Ciancio MC, Orlowski A, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. PMID: 24478712.

Moon JY. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-45. PMID: 24627703.

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