LKT Labs

Biochemicals for Life Science Research

Sarcophine

Sarcophine

Product ID S0368
Cas No. 55038-27-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $188.00 Please Inquire
10 mg $338.00 In stock
Bulk Quote

Quicklinks

Description

Sarcophine is a marine cembranoid diterpene found in the Red Sea soft coral Sarcophyton glaucum. Sarcophine and its synthetic derivative, sarcophine-diol, exhibit chemopreventive activity. In vivo, sarcophine inhibits skin carcinogenesis induced by NOR-1 and TPA. Sarcophine also decreases membrane permeability towards Ca2+, increases degradation of PLA and PLC, and decreases levels of COX-2, inhibiting the tumor formation in melanoma models. In breast cancer and prostate cancer cell lines, sarcophine inhibits cell migration. Sarcophine may also inhibit phosphofructokinase.

Product Info

Cas No.

55038-27-2
Purity

≥98%
Formula

C20H28O3
Formula Wt.

316.43
IUPAC Name

(1S,2E,6S,8S,11E)-3,8,12,16-tetramethyl-7,18-dioxatricyclo[13.3.0.06,8]octadeca-2,11,15-trien-17-one
Appearance

White Crystal

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

S0368 MSDS PDF
Info Sheet

S0368 Info Sheet PDF

References

Szymanski PT, Ahmed SA, Khalifa S, et al. Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS:HR-1 mice. Nat Prod Commun. 2013 Feb;8(2):153-4. PMID: 23513714.

Szymanski PT, Muley P, Ahmed SA, et al. Sarcophine-diol inhibits expression of COX-2, inhibits activity of cPLA2, enhances degradation of PLA2 and PLC(γ)1 and inhibits cell membrane permeability in mouse melanoma B16F10 cells. Mar Drugs. 2012 Oct;10(10):2166-80. PMID: 23170076.

Hassan HM, Sallam AA, Mohammed R, et al. Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors. Bioorg Med Chem. 2011 Aug 15;19(16):4928-34. PMID: 21775154.

Erman A, Neéman I. Inhibition of phosphofructokinase by the toxic cembranolide sarcophine isolated from the soft-bodied coral Sarcophyton glaucum. Toxicon. 1977;15(3):207-15. PMID: 17178.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T7676

    HT-2 Toxin

    Trichothecene mycotoxin produced by Fusarium.

    ≥98%, TLC, HPLC
  • A0918

    N-Acetyl-L-Cysteine

    Cysteine derivative, antioxidant, ROS scavenger...

    ≥98%
  • T291321

    Thiamine Mononitrate

    Vitamin B1

    ≥98%
  • R3221

    3-Formylrifamycin

    Rifamycin derivative, induces pore formation in...

    ≥98%
  • V0146

    Valsartan

    AT1 inhibitor.

    ≥98%
  • E0403

    Ebastine

    Histamine H1 antagonist.

    ≥98%
  • C2949

    Chlorpheniramine Maleate

    Alkylamine; histamine H1 antagonist, SERT and N...

    ≥98%
  • A5044

    Amlodipine Besylate

    Dihydropyridine, FIASMA; L-type Ca2+ channel bl...

    ≥98%
  • R0020

    RAF265

    B-Raf, VEGFR2, c-Raf, PDGFR, CSF-1R, RET, c-Kit...

    ≥98%
  • K1653

    Kendomycin

    Macrolide; ET antagonist, proteasome inhibitor....

    ≥98%
  • G571344

    (±)-Goitrin

    Reduces production of thyroid hormones

    ≥98%
  • H2980

    Humanin, human

    Endogenous peptide; FPRL1/2 agonist.

    ≥95%
  • S6232

    Spiramycin

    Macrolide; protein synthesis inhibitor. ≥3900...

    ≥3900 IU/mg
  • B011458

    Baloxavir

    Cap-dependent endonuclease inhibitor

    ≥ 99%
  • P7359

    Psoralidin

    Phenol found in Psoralea coryfolia.

    ≥98%
  • E9416

    Exendin-3

    Peptide, GLP-1 analog found in Heloderma; GLP-1...

    ≥95%
  • R5894

    Roxatidine Acetate Hydrochloride

    Histamine H2 antagonist.

    ≥98%
  • A5030

    4-Aminophenylphosphate Monosodium

    Alkaline phosphatase substrate used to quantify...

    ≥97%
  • S7868

    SRT1720 Hydrochloride

    SIRT 1 activator, SIRT3 inhibitor.

    ≥98%
  • T5846

    Tolfenamic Acid

    NSAID; COX-1/2 inhibitor.

    ≥98%