Sarcophine

Name: Sarcophine
SKU: S0368
Availability: InStock

Product ID S0368

Cas No. 55038-27-2

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Sarcophine is a marine cembranoid diterpene found in the Red Sea soft coral Sarcophyton glaucum. Sarcophine and its synthetic derivative, sarcophine-diol, exhibit chemopreventive activity. In vivo, sarcophine inhibits skin carcinogenesis induced by NOR-1 and TPA. Sarcophine also decreases membrane permeability towards Ca2+, increases degradation of PLA and PLC, and decreases levels of COX-2, inhibiting the tumor formation in melanoma models. In breast cancer and prostate cancer cell lines, sarcophine inhibits cell migration. Sarcophine may also inhibit phosphofructokinase.

Product Info

Cas No.	55038-27-2
Purity	≥98%
Formula	C₂₀H₂₈O₃
Formula Wt.	316.43
IUPAC Name	(1S,2E,6S,8S,11E)-3,8,12,16-tetramethyl-7,18-dioxatricyclo[13.3.0.06,8]octadeca-2,11,15-trien-17-one
Appearance	White Crystal

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	S0368 MSDS PDF
Info Sheet	S0368 Info Sheet PDF

References

Szymanski PT, Ahmed SA, Khalifa S, et al. Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS:HR-1 mice. Nat Prod Commun. 2013 Feb;8(2):153-4. PMID: 23513714.

Szymanski PT, Muley P, Ahmed SA, et al. Sarcophine-diol inhibits expression of COX-2, inhibits activity of cPLA2, enhances degradation of PLA2 and PLC(γ)1 and inhibits cell membrane permeability in mouse melanoma B16F10 cells. Mar Drugs. 2012 Oct;10(10):2166-80. PMID: 23170076.

Hassan HM, Sallam AA, Mohammed R, et al. Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors. Bioorg Med Chem. 2011 Aug 15;19(16):4928-34. PMID: 21775154.

Erman A, Neéman I. Inhibition of phosphofructokinase by the toxic cembranolide sarcophine isolated from the soft-bodied coral Sarcophyton glaucum. Toxicon. 1977;15(3):207-15. PMID: 17178.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Sarcophine

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Caffeine

Pepstatin

Tirasemtiv

Amlodipine

KL-1 Peptide

Theaflavin-3,3’-digallate

Thioridazine Hydrochloride

Cyproconazole

Patulin

LHRH Acetate Salt

Monascin

Imatinib free base

Docosahexaenoic Acid (all cis-4,7,10,13,16,19) Methyl Ester

Okadaic Acid Ammonium

KB-0742

Asciminib Hydrochloride

Azelnidipine

Triacetyl Aloe-emodin (Impurity A)

Butein

Erythropoietin, Human Recombinant

Footer