Sarcophine

Name: Sarcophine
SKU: S0368
Availability: InStock

Product ID S0368

Cas No. 55038-27-2

Purity ≥98%

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Description

Sarcophine is a marine cembranoid diterpene found in the Red Sea soft coral Sarcophyton glaucum. Sarcophine and its synthetic derivative, sarcophine-diol, exhibit chemopreventive activity. In vivo, sarcophine inhibits skin carcinogenesis induced by NOR-1 and TPA. Sarcophine also decreases membrane permeability towards Ca2+, increases degradation of PLA and PLC, and decreases levels of COX-2, inhibiting the tumor formation in melanoma models. In breast cancer and prostate cancer cell lines, sarcophine inhibits cell migration. Sarcophine may also inhibit phosphofructokinase.

Product Info

Cas No.	55038-27-2
Purity	≥98%
Formula	C₂₀H₂₈O₃
Formula Wt.	316.43
IUPAC Name	(1S,2E,6S,8S,11E)-3,8,12,16-tetramethyl-7,18-dioxatricyclo[13.3.0.06,8]octadeca-2,11,15-trien-17-one
Appearance	White Crystal

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	S0368 MSDS PDF
Info Sheet	S0368 Info Sheet PDF

References

Szymanski PT, Ahmed SA, Khalifa S, et al. Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS:HR-1 mice. Nat Prod Commun. 2013 Feb;8(2):153-4. PMID: 23513714.

Szymanski PT, Muley P, Ahmed SA, et al. Sarcophine-diol inhibits expression of COX-2, inhibits activity of cPLA2, enhances degradation of PLA2 and PLC(γ)1 and inhibits cell membrane permeability in mouse melanoma B16F10 cells. Mar Drugs. 2012 Oct;10(10):2166-80. PMID: 23170076.

Hassan HM, Sallam AA, Mohammed R, et al. Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors. Bioorg Med Chem. 2011 Aug 15;19(16):4928-34. PMID: 21775154.

Erman A, Neéman I. Inhibition of phosphofructokinase by the toxic cembranolide sarcophine isolated from the soft-bodied coral Sarcophyton glaucum. Toxicon. 1977;15(3):207-15. PMID: 17178.

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Sarcophine

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