LKT Labs

Biochemicals for Life Science Research

Sarcophine

Sarcophine

Product ID S0368
Cas No. 55038-27-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $188.00 Please Inquire
10 mg $338.00 In stock
Bulk Quote

Quicklinks

Description

Sarcophine is a marine cembranoid diterpene found in the Red Sea soft coral Sarcophyton glaucum. Sarcophine and its synthetic derivative, sarcophine-diol, exhibit chemopreventive activity. In vivo, sarcophine inhibits skin carcinogenesis induced by NOR-1 and TPA. Sarcophine also decreases membrane permeability towards Ca2+, increases degradation of PLA and PLC, and decreases levels of COX-2, inhibiting the tumor formation in melanoma models. In breast cancer and prostate cancer cell lines, sarcophine inhibits cell migration. Sarcophine may also inhibit phosphofructokinase.

Product Info

Cas No.

55038-27-2
Purity

≥98%
Formula

C20H28O3
Formula Wt.

316.43
IUPAC Name

(1S,2E,6S,8S,11E)-3,8,12,16-tetramethyl-7,18-dioxatricyclo[13.3.0.06,8]octadeca-2,11,15-trien-17-one
Appearance

White Crystal

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

S0368 MSDS PDF
Info Sheet

S0368 Info Sheet PDF

References

Szymanski PT, Ahmed SA, Khalifa S, et al. Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS:HR-1 mice. Nat Prod Commun. 2013 Feb;8(2):153-4. PMID: 23513714.

Szymanski PT, Muley P, Ahmed SA, et al. Sarcophine-diol inhibits expression of COX-2, inhibits activity of cPLA2, enhances degradation of PLA2 and PLC(γ)1 and inhibits cell membrane permeability in mouse melanoma B16F10 cells. Mar Drugs. 2012 Oct;10(10):2166-80. PMID: 23170076.

Hassan HM, Sallam AA, Mohammed R, et al. Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors. Bioorg Med Chem. 2011 Aug 15;19(16):4928-34. PMID: 21775154.

Erman A, Neéman I. Inhibition of phosphofructokinase by the toxic cembranolide sarcophine isolated from the soft-bodied coral Sarcophyton glaucum. Toxicon. 1977;15(3):207-15. PMID: 17178.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L1784

    Levetiracetam

    SV2A synaptic vesicle inhibitor.

    ≥99%
  • F4481

    Flurbiprofen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • C0273

    Casin

    Cdc42 GTPase inhibitor.

    ≥97%
  • T3033

    Thienyldodecyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • D3228

    Dihydromyristicin

    Found in parsley.

    ≥98%
  • E4668

    ELR-510444

    Microtubule polymerization inhibitor.

    ≥98%
  • T1855

    Tentoxin

    Cyclic peptide mycotoxin produced by Alternaria...

    ≥98%, HPLC
  • D3208

    Diclazuril

    Coccidiostat, GAPDH inhibitor.

    ≥98%
  • J0274

    Jasplakinolide

    Marine toxin; actin polymerization inducer.

    ≥98%
  • F4682

    Fluconazole

    Triazole; 14-α demethylase inhibitor.

    ≥98%
  • T6834

    Triacsin C

    Acyl-CoA synthetase inhibitor.

    ≥95%
  • S7717

    Sterigmatocystin

    Mycotoxin produced by Aspergillus; carcinogen.<...

    ≥98%
  • L5749

    Lomefloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • A6800

    AR-A014418

    GSK-3β inhibitor.

    ≥98%
  • S7872

    Stresscopin-Related Peptide, human

    Peptide, urocortin II analog; CRFR2 agonist.

    ≥95%
  • O938565

    6-Oxodocetaxel

    Docetaxel impurity

    ≥98%
  • V3253

    Vinblastine Sulfate

    Vinca alkaloid found in Catharanthus; microtubu...

    ≥96%
  • U698578

    Urolithin C

    Ellagic acid derivative produced by gut microfl...

    ≥98%
  • N5605

    Nobiletin

    Polymethoxylated flavone found in citrus fruits...

    ≥97%
  • R5772

    Rosiglitazone Maleate

    Thiazolidinedione; PPARγ agonist.

    ≥98%