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Scopolamine is a tropane alkaloid found in Solanaceae family plants that exhibits antiemetic and anticholinergic activities. Scopolamine inhibits muscarinic acetylcholine receptors (mAChRs) with a moderate selectivity for M1 mAChRs. Scopolamine is used to induce cognitive deficits in animal models of Alzheimer’s disease. Additionally, scopolamine displays some antidepressant activity and has previously been used in the treatment of organophosphate poisoning.
| Cas No. | 6533-68-2 |
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| Purity | ≥98% |
| Formula | C17H21NO4 • HBr • 3H2O |
| Formula Wt. | 438.32 |
| IUPAC Name | [(1S,2S,4R,5R)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate;trihydrate;hydrobromide |
| Synonym | Scopolamine hydrobromide, Scopolammonium |
| Melting Point | 195°C |
| Solubility | Soluble in water (≥600 mg/mL), ethanol (50 mg/mL). Slightly soluble in chloroform. |
| Appearance | White Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Jung IH, Lee HE, Park SJ, et al. Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice. Pharmacol Biochem Behav. 2014 May;120:88-94. PMID: 24582850.
Drevets WC, Zarate CA Jr, Furey ML. Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review. Biol Psychiatry. 2013 Jun 15;73(12):1156-63. PMID: 23200525.