• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Simufilam Dihydrochloride

Simufilam Dihydrochloride

Product ID S336507
Cas No. 2480226-06-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $165.40 In stock
25 mg $468.60 In stock
100 mg $1,080.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Simufilam was first introduced as having the potential to reduce biomarkers of Alzheimer’s disease. The original data has since become suspect and could not be found. Fraud charges have been filed by the SEC. Simufilam may or may not have some useful bioactivities. The proper research, with proper data collection and analysis, is still to be done.

Product Info

Cas No.

2480226-06-8

Purity

≥98%

Formula

C15H23Cl2N3O

Formula Wt.

332.3

Chemical Name

4-benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-3-one;dihydrochloride

IUPAC Name

4-benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-3-one;dihydrochloride

Synonym

PTI-125 dihydrochloride; PTI diHCl; JP8XRG9A58

Solubility

DMSO (>60 mg/mL), water (>60 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

S336507 Info Sheet PDF

References

Pillar C. Research backing experimental Alzheimer’s drug was first target of suspicion. Science. 2022 Jul 22;377(6604):363. PMID: 35862516

Pillar C. Probe of Alzheimer’s studies finds ‘egregious misconduct’. Science. 2023 Oct 20;382(6668):251-252. PMID: 37856608

Dyer O. Scientist who worked on Cassava’s Alzheimer drug simufilam charged with fraud. BMJ. 2024 Jul 15: 386:q1568. PMID: 39009358

Frontiers Editorial Office. Expression of concern: simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer’s disease patient lymphocytes. Front Aging. 2024 Aug 22:5:1483030. PMID: 39239266

Pillar C. Firm misled investors on Alzheimer’s drug, SEC charges. Science. 2024 Oct 4;386(6717):15. PMID: 39361735

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M1975

    S-(N-Methylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant; aldehyde d...

    ≥98%
  • T3305

    Tibolone

    Synthetic steroid hormone used in HRT; SERM, PR...

    ≥98%
  • A5373

    Anisomycin

    Peptidyl transferase inhibitor, protein transla...

    ≥98%
  • S041001

    SB-202190

    Highly selective inhibitor

    ≥99%
  • K0030

    Kahweol

    Diterpene found in coffee beans.

    ≥97%
  • L0360

    Lapatinib Ditosylate Monohydrate

    EGFR inhibitor.

    ≥99%
  • C822706

    Curvularin

    Macrocyclic lactone.

    ≥98%
  • C4646

    Clofarabine

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • M568270

    Mogroside V

    Triterpenoid

    ≥98%
  • R5894

    Roxatidine Acetate Hydrochloride

    Histamine H2 antagonist.

    ≥98%
  • V574451

    Volitinib

    c-Met inhibitor.

    ≥98%
  • R3586

    Rivastigmine Tartrate

    AChE and BChE inhibitor.

    ≥99%
  • A4577

    Alsterpaullone

    GSK-3 and CDK inhibitor.

    ≥98%
  • C8502

    CV-70

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • A2532

    AGI-6780

    Isocitrate dehydrogenase inhibitor.

    ≥98%
  • G4535

    Glimepiride

    Sulfonylurea; ATP-sensitive K+ channel blocker....

    ≥98%
  • M1777

    R-(−)-α-Methylbenzyl Isothiocyanate

    ITC, used as chiral agent.

    ≥98%
  • I6932

    Irinotecan

    Camptothecin analog; topoisomerase I inhibitor,...

    ≥98%
  • B1874

    Bestatin Hydrochloride

    Dipeptide; aminopeptidase (N/CD13) inhibitor.

    ≥98%
  • T2932

    Thiamphenicol Glycinate Hydrochloride

    Chloramphenicol derivative; protein translation...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only