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SIS3 Hydrochloride

SIS3 Hydrochloride

Product ID S343720
Cas No. 521984-48-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $89.30 Please Inquire
5 mg $236.30 Please Inquire
25 mg $551.30 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SIS3 is a selective inhibitor of Smad3. Smad3 functions downstream of TGF-β and activin receptors, mediating their signaling. SIS3 suppresses Smad3 phosphorylation, thus inhibiting TGF-β and activin signaling independent of the MAPK, ERK, and PI3K pathways.

Product Info

Cas No.

521984-48-5

Purity

≥98%

Formula

C28H28ClN3O3

Formula Wt.

490.00

IUPAC Name

1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride

Synonym

SIS3 HCl; CTK8E8838; KS-00000UAU

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

S343720 MSDS PDF

Info Sheet

S343720 Info Sheet PDF

References

Jinnin M., Ihn H., et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 69(2):597-607 (2006). PMID: 16288083.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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