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Streptozocin is a nitrosourea-amino sugar conjugate initially produced by species of Streptomyces that exhibits pro-diabetic, antibacterial, and anticancer activities. Streptozocin is toxic to pancreatic islet β cells and is often used to induce diabetes-like conditions in animal models. Streptozocin has also been examined as a potential treatment for cancers of β cells.
| Cas No. | 18883-66-4 |
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| Purity | ≥98% |
| Formula | C8H15N3O7 |
| Formula Wt. | 265.22 |
| Chemical Name | 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucopyranose |
| IUPAC Name | 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4, 5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea InChI: InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7, 12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1 |
| Synonym | Streptozotocin, NSC-85998, U-9889, Zanosar |
| Melting Point | 121°C (dec) |
| Solubility | Soluble in water, ketones and lower alcohols. |
| Appearance | Pale Yellow Crystalline Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Rerup CC. Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev. 1970 Dec;22(4):485-518. PMID: 4921840.
Murray-Lyon IM, Eddleston AL, Williams R, et al. Treatment of multiple-hormone-producing malignant islet-cell tumour with streptozotocin. Lancet. 1968 Oct 26;2(7574):895-8. PMID: 4176152.
Vavra JJ, Deboer C, Dietz A, et al. Streptozotocin, a new antibacterial antibiotic. Antibiot Annu. 1959-1960;7:230-5. PMID: 13841501.