LKT Labs

Biochemicals for Life Science Research

Tanshinone I

Product ID T0153
Cas No. 568-73-0
Purity ≥95%
Product Unit SizeCostQuantityStock
10 mg $136.10 In stock
25 mg $291.60 In stock
100 mg $933.30 In stock
Bulk Quote

Quicklinks

Description

Tanshinone I is a diterpene found in Salvia that exhibits neuroprotective, anti-inflammatory, antioxidative, anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. Tanshinone I upregulates expression of IL-4 and IL-13, protecting against cerebral ischemia/reperfusion-induced injury in vivo. Tanshinone I also decreases peroxynitrite-induced DNA damage and radical formation. Additionally, tanshinone I inhibits expression of VEGF, cyclin A, cyclin B, and AurA in various models of lung cancer, inhibiting cellular and tumor growth.

Product Info

Cas No.

568-73-0
Purity

≥95%
Formula

C18H12O3
Formula Wt.

276.29
Chemical Name

1,6-Dimethylphenanthro(1,2-b)furan-10,11-dione

IUPAC Name

1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione
Synonym

Tanshinone A
Melting Point

233-234°C
Solubility

Soluble in DMSO.
Appearance

Dark purple crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

T0153 MSDS PDF
Info Sheet

T0153 Info Sheet PDF

References

Park JH, Park OK, Cho JH, et al. Anti-inflammatory Effect of Tanshinone I in Neuroprotection Against Cerebral Ischemia-Reperfusion Injury in the Gerbil Hippocampus. Neurochem Res. 2014 Apr 24. [Epub ahead of print]. PMID: 24760430.

Zhou S, Chen W, Su H, et al. Protective properties of tanshinone I against oxidative DNA damage and cytotoxicity. Food Chem Toxicol. 2013 Dec;62:407-12. PMID: 24021569.

Tung YT, Chen HL, Lee CY, et al. Active Component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, Attenuates Lung Tumorigenesis via Inhibitions of VEGF, Cyclin A, and Cyclin B Expressions. Evid Based Complement Alternat Med. 2013;2013:319247. PMID: 23662128.

Tao S, Zheng Y, Lau A, et al. Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo. Antioxid Redox Signal. 2013 Nov 10;19(14):1647-61. PMID: 23394605.

Li Y, Gong Y, Li L, et al. Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function. Mol Carcinog. 2013 Jul;52(7):535-43. PMID: 22389266.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

Zhang Y, Won SH, Jiang C, et al. Tanshinones fmor Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling. Pharm Res. 2012 Jun;29(6):1595-1608. PMID: 22281759.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5056

    Amorolfine Hydrochloride

    14α-demethylase inhibitor.

    ≥98.5%
  • A4854

    β-Amyloid Peptide (1-42), rat

    Endogenous APP peptide cleavage product, primar...

    ≥95%
  • P2002

    PF-04691502 Dihydrate

    PI3K and mTOR inhibitor.

    ≥98%
  • M400220

    MK-2206 Dihydrochloride

    Akt inhibitor.

    ≥99%
  • L9704

    LY-2603618

    Chk1 inhibitor.

    ≥98%
  • D4873

    Meso-2,3-dimercaptosuccinic Acid

    Organosulfur, chelating agent.

    ≥98%
  • S8049

    S-Sulforaphene

    Isothiocyanate found in cruciferous vegetables....

    ≥98%
  • C0263

    L-Carnitine Hydrochloride

    Endogenous quaternary ammonium, required for fa...

    ≥98%
  • O7332

    OSI-027

    mTOR inhibitor.

    ≥99%
  • D1792

    Dextromethorphan Hydrobromide Hydrate

    σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7...

    ≥98%
  • S8345

    S-(−)-Sulpiride

    GHB agonist, D2/3 antagonist.

    ≥99%
  • G1210

    GDC-0623

    MEK inhibitor.

    ≥98%
  • C3576

    Citreoviridin A

    Mycotoxin; F1F0 ATP synthase inhibitor.

    ≥95%
  • N8663

    NVP-LDE225 Diphosphate

    Smo inhibitor.

    ≥98%
  • C0151

    α-Calcitonin Gene Related Peptide, human

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • I7458

    1-Isothiocyanato-9-(methylsulfinyl)-nonane

    ITC, sulforaphane analog.

    ≥98%
  • I0516

    I-BET151

    BRD2/3/4 inhibitor.

    ≥98%
  • Q8016

    Quercetin Dihydrate

    Flavonoid found in fruits, vegetables, and grai...

    ≥95%
  • A6804

    Arbutin

    Glycoside hydroquinone originally found in Berg...

    ≥98%
  • B1652

    Benzo[a]pyrene

    Polycyclic aromatic hydrocarbon (PAH) found in ...

    ≥98%