LKT Labs

Biochemicals for Life Science Research

Tanshinone I

Tanshinone I

Product ID T0153
Cas No. 568-73-0
Purity ≥95%
Product Unit SizeCostQuantityStock
10 mg $142.90 In stock
25 mg $306.20 In stock
100 mg $980.00 In stock
Bulk Quote

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Description

Tanshinone I is a diterpene found in Salvia that exhibits neuroprotective, anti-inflammatory, antioxidative, anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. Tanshinone I upregulates expression of IL-4 and IL-13, protecting against cerebral ischemia/reperfusion-induced injury in vivo. Tanshinone I also decreases peroxynitrite-induced DNA damage and radical formation. Additionally, tanshinone I inhibits expression of VEGF, cyclin A, cyclin B, and AurA in various models of lung cancer, inhibiting cellular and tumor growth.

Product Info

Cas No.

568-73-0
Purity

≥95%
Formula

C18H12O3
Formula Wt.

276.29
Chemical Name

1,6-Dimethylphenanthro(1,2-b)furan-10,11-dione

IUPAC Name

1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione
Synonym

Tanshinone A
Melting Point

233-234°C
Solubility

Soluble in DMSO.
Appearance

Dark purple crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

T0153 MSDS PDF
Info Sheet

T0153 Info Sheet PDF

References

Park JH, Park OK, Cho JH, et al. Anti-inflammatory Effect of Tanshinone I in Neuroprotection Against Cerebral Ischemia-Reperfusion Injury in the Gerbil Hippocampus. Neurochem Res. 2014 Apr 24. [Epub ahead of print]. PMID: 24760430.

Zhou S, Chen W, Su H, et al. Protective properties of tanshinone I against oxidative DNA damage and cytotoxicity. Food Chem Toxicol. 2013 Dec;62:407-12. PMID: 24021569.

Tung YT, Chen HL, Lee CY, et al. Active Component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, Attenuates Lung Tumorigenesis via Inhibitions of VEGF, Cyclin A, and Cyclin B Expressions. Evid Based Complement Alternat Med. 2013;2013:319247. PMID: 23662128.

Tao S, Zheng Y, Lau A, et al. Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo. Antioxid Redox Signal. 2013 Nov 10;19(14):1647-61. PMID: 23394605.

Li Y, Gong Y, Li L, et al. Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function. Mol Carcinog. 2013 Jul;52(7):535-43. PMID: 22389266.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

Zhang Y, Won SH, Jiang C, et al. Tanshinones fmor Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling. Pharm Res. 2012 Jun;29(6):1595-1608. PMID: 22281759.

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