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Taxinine M is a taxane compound originally found in species of the yew tree under the Taxus genus. Taxinines inhibit DNA polymerase. Taxinine M displays anticancer activity, inhibiting lung cancer cell proliferation. Like other taxanes, taxinine M may also promote microtubule polymerization and prevent microtubule depolymerization. However, in tests on human epidermoid carcinoma KB cells, taxinin M showed little or no effect.
| Cas No. | 135730-55-1 |
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| Purity | ≥98% |
| Formula | C35H42NO14 |
| Formula Wt. | 686.7 |
| Chemical Name | Taxinin M |
| IUPAC Name | [(1R,2R,3S,4R,5R,6S,8S,10R,11R,12R,15S)-3,4,6,11-tetraacetyloxy-2,8-dihydroxy-1,15-dimethyl-9-methylidene-14-oxo-16-oxatetracyclo[10.5.0.02,15.05,10]heptadecan-5-yl]methyl benzoate |
| Synonym | Taxinine M |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Li Y, Qin F, Wang SM, et al. Chemical studies on Taxus canadensis. Chem Biodivers. 2013 Oct;10(10):1729-53. PMID: 24130020.
Oshige M, Takenouchi M, Kato Y, et al. Taxol derivatives are selective inhibitors of DNA polymerase alpha. Bioorg Med Chem. 2004 May 15;12(10):2597-601. PMID: 15110841.
Prasain JK, Stefanowicz P, Kiyota T, et al. Taxines from the needles of Taxus wallichiana. Phytochemistry. 2001 Dec;58(8):1167-70. PMID: 11738401.
Kobayashi J, Shigemori H, Hosoyama H, et al. Multidrug resistance reversal activity of taxoids from Taxus cuspidata in MB-C2 and 2780AD cells. Jpn J Cancer Res. 2000 Jun;91(6):638-642. PMID: 10874217.
Beutler JA, Chmurny GM, Look SA, et al. Taxinine M, a new tetracyclic taxane from Taxus brevifolia. J Nat Prod. 1991 May-Jun;54(3):893-7. PMID: 1955887.