LKT Labs

Biochemicals for Life Science Research

TG101348

Product ID T2404
Cas No. 936091-26-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.40 Please Inquire
5 mg $185.10 In stock
10 mg $281.30 Please Inquire
Bulk Quote

Quicklinks

Description

TG101348 is an inhibitor of JAK2 that is currently in clinical trials as a potential treatment for myelofibrosis. TG101348 exhibits immunomodulatory and anticancer chemotherapeutic activities. In cells acquired from acute coronary syndrome patients, TG101348 decreases expression of Th17 cells and increases expression of Treg cells. TG101348 inhibits cellular proliferation of Hodgkin lymphoma cells and mediastinal large B-cell lymphoma cells; in vivo, this compound decreases tumor growth and increases survival. In animal models of myeloproliferative disease, TG101348 decreases hematocrit and leukocyte count, somewhat attenuating myelofibrosis.

Product Info

Cas No.

936091-26-8
Purity

≥98%
Formula

C27H36N6O3S
Formula Wt.

524.68
IUPAC Name

N-(2-Methyl-2-propanyl)-3-{[5-methyl-2-({4-[2-(1-pyrrolidinyl)ethoxy]phenyl}amino)-4-pyrimidinyl]amino}benzenesulfonamide
Synonym

SAR302503, Fedratinib
Solubility

DMSO 100 mg/mL (190.59 mM) Water Insoluble Ethanol Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T2404 MSDS PDF
Info Sheet

T2404 Info Sheet PDF

References

Zheng Y, Wang Z, Deng L, et al. Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients with acute coronary syndrome. Clin Immunol. 2015 Jan 5;157(1):65-77. PMID: 25572535.

Hao Y, Chapuy B, Monti S, et al. Selective JAK2 inhibition specifically decreases Hodgkin lymphoma and mediastinal large B-cell lymphoma growth in vitro and in vivo. Clin Cancer Res. 2014 May 15;20(10):2674-83. PMID: 24610827.

Zhang M, Xu CR, Shamiyeh E, et al. A randomized, placebo-controlled study of the pharmacokinetics, pharmacodynamics, and tolerability of the oral JAK2 inhibitor fedratinib (SAR302503) in healthy volunteers. J Clin Pharmacol. 2014 Apr;54(4):415-21. PMID: 24165976.

Wernig G, Kharas MG, Okabe R, et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell. 2008 Apr;13(4):311-20. PMID: 18394554.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4521

    Alfacalcidol

    Vitamin D analog.

    ≥98%
  • A7656

    Atomoxetine Hydrochloride

    NET and SERT inhibitor, NMDA antagonist.

    ≥99%
  • P7318

    Pseudoginsenoside F11

    Saponin found in species of Panax; PPARγ agoni...

    ≥98%
  • A9600

    AZD-3463

    ALK and IGF-1R inhibitor.

    ≥99%
  • K0117

    Kaempferol

    Flavonol found in various plant sources.

    ≥98%
  • T3196

    Thymoquinone

    Phytochemical from Nigella sativa.

    ≥98%
  • O9201

    Oxaliplatin

    Pt-based DNA cross-linker.

    ≥98%
  • A5160

    Ampicillin Trihydrate

    β-lactam; transpeptidase inhibitor.

    ≥97%
  • H9803

    Hyaluronic Acid Sodium (0.2 -5 kDA)

    Glycosaminoglycan
  • F3206

    Fibrinolysis Inhibiting Factor

    Peptide; fibrinolysis inhibitor.

    ≥98%
  • O9257

    16-Oxokahweol

    Synthetic kahweol derivative.

    ≥95%
  • A7604

    ATB 346

    NSAID; COX inhibitor and HS-releasing agent.

    ≥99%
  • P2100

    PF-06447475

    LRRK2 inhibitor.

    ≥98%
  • M017545

    Manumycin A

    Natural antibiotic found in Streptomyces parvul...

    ≥97%
  • S0244

    Salsalate

    Salicylic acid prodrug, NSAID; weak COX-1/2 inh...

    ≥95%
  • P0001

    P1 Peptide

    Octapeptide, prevents EGFR-PLCγ association.

    ≥95%
  • T1777

    S,S-(+)-Tetrandrine

    Benzylisoquinoline alkaloid originally found in...

    ≥98%
  • P3462

    Piperacillin

    β-lactam; penicillin binding protein inhibitor...

    ≥95%
  • N5655

    Nonoxynol-9

    Nonoxynol surfactant.

    90-110%
  • D4873

    Meso-2,3-dimercaptosuccinic Acid

    Organosulfur, chelating agent.

    ≥98%