LKT Labs

Biochemicals for Life Science Research

Thymopentin Acetate

Product ID T3094
Cas No. 69558-55-0
Purity ≥95%
Product Unit SizeCostQuantityStock
10 mg $124.90 Please Inquire
50 mg $540.00 Please Inquire
1 g $1,993.60 Please Inquire
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Description

Thymopentin is a five amino acid peptide fragment of thymopoietin that exhibits immunostimulatory and anticancer activities. Thymopentin decreases iNOS activity in the treatment of Sezary Syndrome, a severe form of lymphoma. In leukemia cells, thymopentin inhibits proliferation and colony formation and induces differentiation. In macrophages, thymopentin increases pro-inflammatory cytokine secretion, activation of NF-κB, production of HSP72, and signaling by JNK. Thymopentin shows clinical benefit when used as an adjuvant, improving the response rate in subjects administered hepatitis B vaccines.

Product Info

Cas No.

69558-55-0
Purity

≥95%
Formula

C30H49N9O9 CH3COOH
Formula Wt.

679.8
IUPAC Name

(3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino) pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4- hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
Synonym

TP-5 Acetate
Solubility

Freely soluble in water.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T3094 MSDS PDF
Info Sheet

T3094 Info Sheet PDF

References

Patruno A, Tosco P, Borretto E, et al. Thymopentin down-regulates both activity and expression of iNOS in blood cells of Sézary syndrome patients. Nitric Oxide. 2012 Oct 15;27(3):143-9. PMID: 22721692.

Lunin SM, Glushkova OV, Khrenov MO, et al. Thymus peptides regulate activity of RAW 264.7 macrophage cells: inhibitory analysis and a role of signal cascades. Expert Opin Ther Targets. 2011 Dec;15(12):1337-46. PMID: 22148922.

Fan YZ, Chang H, Yu Y, et al. Thymopentin (TP5), an immunomodulatory peptide, suppresses proliferation and induces differentiation in HL-60 cells. Biochim Biophys Acta. 2006 Oct;1763(10):1059-66. PMID: 16952408.

Fabrizi F, Dixit V, Martin P. Meta-analysis: the adjuvant role of thymopentin on immunological response to hepatitis B virus vaccine in end-stage renal disease. Aliment Pharmacol Ther. 2006 Jun 1;23(11):1559-66. PMID: 16696803.

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