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TM3-0089 is an inhibitor of chemoattractant receptor-homologous molecule on Th2 cells (CRTH2), which inhibits prostaglandin activation of Th2 cells. TM3-0089 exhibits anti-allergic and anti-inflammatory activities. TM3-0089 prevents migration of Th2 lymphocytes, calcium influx, and adhesion of lymphocytes to vascular endothelial cells in vitro.
| Cas No. | 844639-57-2 |
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| Purity | ≥98% |
| Formula | C21H20FN2O4SNa • H2O |
| Formula Wt. | 456.46 |
| IUPAC Name | sodium;2-[3-[(4-fluorophenyl)sulfonyl-methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]acetic acid;hydrate |
| Synonym | CAY10471 |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Xue L, Fergusson J, Salimi M, et al. Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk. J Allergy Clin Immunol. 2014 Oct 19. [Epub ahead of print]. PMID: 25441644.
Schröder R, Xue L, Konya V, et al. PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2. PLoS One. 2012;7(3):e33329. PMID: 22442685.
Uller L, Mathiesen JM, Alenmyr L, et al. Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Respir Res. 2007 Feb 28;8:16. PMID: 17328802.