Description
TMS is a selective inhibitor of cytochrome P450 1B1 (CYP1B1), an enzyme which metabolizes endogenous and exogenous xenobiotics. It is 50-fold selective over CYP1A1 and more than 500-fold selective over CYP1A2.
TMS is a selective inhibitor of cytochrome P450 1B1 (CYP1B1), an enzyme which metabolizes endogenous and exogenous xenobiotics. It is 50-fold selective over CYP1A1 and more than 500-fold selective over CYP1A2.
| Cas No. | 24144-92-1 |
|---|---|
| Purity | ≥99% |
| Formula | C18H20O4 |
| Formula Wt. | 300.35 |
| Chemical Name | (E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene |
| IUPAC Name | 1-[(E)-2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene |
| Synonym | 2,3',4,5'-Tetramethoxystilbene; 2,4,3',5'-tetramethoxystilbene; 3,5,2',4'-tetramethoxy-trans-stilbene; AC1NS4S6; Oxyresveratrol tetramethyl ether |
| Solubility | 100mg/mL in DMSO 6mg/mL in MeOH |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Kim S., Hyojin K., et al. Design, Synthesis, and Discovery of Novel trans-Stilbene Analogues as Potent and Selective Human Cytochrome P450 1B1 Inhibitors. J Med Chem. 45(1):160-164 (2001). PMID: 11754588.
Pyrimidine, glucose analog, used to induce diab...
Endogenous neuropeptide hormone, lowers extrace...
Endogenous glycoprotein; lactoferrin agonist.
Pyramido-pyrrolo-quinoxalinedione; CFTR blocker...
Benzimidazole; microtubule polymerization inhib...
β-lactam cephalosporin; penicillin binding pro...
Pleuromutilin
Dual mTORC1/mTORC2 inhibitor.
Snake venom found in Bothrops neuwiedi diporus;...
Found in Piper longum; TxA2 antagonist, ubiquit...
Dipeptide.
Benzamide; HDAC1 inhibitor.
Six-histidine peptide used for affinity column ...
Aurora kinase A inhibitor
Triazolothienodiazepine; BRD inhibitor.
Chloroethylnitrosourea, DNA alkylator and cross...
Valsartan impurity
Thienopyridine; P2Y12 antagonist.
Thiopurine antimetabolite; PRPP amidotransferas...
AT1 inhibitor.