Description
TMS is a selective inhibitor of cytochrome P450 1B1 (CYP1B1), an enzyme which metabolizes endogenous and exogenous xenobiotics. It is 50-fold selective over CYP1A1 and more than 500-fold selective over CYP1A2.
TMS is a selective inhibitor of cytochrome P450 1B1 (CYP1B1), an enzyme which metabolizes endogenous and exogenous xenobiotics. It is 50-fold selective over CYP1A1 and more than 500-fold selective over CYP1A2.
Cas No. | 24144-92-1 |
---|---|
Purity | ≥99% |
Formula | C18H20O4 |
Formula Wt. | 300.35 |
Chemical Name | (E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene |
IUPAC Name | 1-[(E)-2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene |
Synonym | 2,3',4,5'-Tetramethoxystilbene; 2,4,3',5'-tetramethoxystilbene; 3,5,2',4'-tetramethoxy-trans-stilbene; AC1NS4S6; Oxyresveratrol tetramethyl ether |
Solubility | 100mg/mL in DMSO 6mg/mL in MeOH |
Store Temp | Ambient |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Kim S., Hyojin K., et al. Design, Synthesis, and Discovery of Novel trans-Stilbene Analogues as Potent and Selective Human Cytochrome P450 1B1 Inhibitors. J Med Chem. 45(1):160-164 (2001). PMID: 11754588.
MEK1/2 and Raf inhibitor.
Peptide; GABA potentiator, NMDA negative allost...
Heterocyclic derivative of cysteine, alters pro...
Peptide toxin found in Conus snails; nAChR inhi...
β1-adrenergic antagonist.
Voltage-gated K+ channel blocker.
PLK1 inhibitor.
FIASMA, mAChR, 5-HT2/3/6/7, α1/2-adrenergic an...
Promotes Aβ clearance.
Impurity of diclofenac
GSK-3 inhibitor.
β2-adrenergic agonist, BChE inhibitor.
Natriuretic, vasodilatory peptide, bradykinin a...
Mycotoxin produced by Aspergillus; actin polyme...
Potential ATP-sensitive K+ channel blocker, pot...
Podophyllotoxin derivative found in Podophyllum...
β-lactam; penicillin binding protein inhibitor...
Statin; HMG-CoA reductase inhibitor.
Cysteine adduct inducer, PARP-1 inhibitor.
Dipeptide; aminopeptidase (N/CD13) inhibitor.