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Torin 2

Torin 2

Product ID T5871
Cas No. 1223001-51-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $157.80 In stock
10 mg $276.20 In stock
25 mg $575.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Torin 2 is a tricyclic benzonaphthyridinone that inhibits mTORC1/2 and exhibits anticancer activity. In hepatocellular carcinoma cells, torin 2 inhibits cell growth and survival and induces apoptosis and autophagy. In acute lymphoblastic leukemia (ALL) cells, torin 2 induces G0/G1 phase cell cycle arrest and inhibits cell growth.

Product Info

Cas No.

1223001-51-1

Purity

≥98%

Formula

C24H15F3N4O

Formula Wt.

432.41

Chemical Name

9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2-one

IUPAC Name

9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one

Synonym

Torin-2

Solubility

20mM in DMSO, insoluble in H2O and ethanol

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T5871 MSDS PDF

Info Sheet

T5871 Info Sheet PDF

References

Wang C, Wang X, Su Z, et al. The novel mTOR inhibitor Torin-2 induces autophagy and downregulates the expression of UHRF1 to suppress hepatocarcinoma cell growth. Oncol Rep. 2015 Oct;34(4):1708-16. PMID: 26239364.

Simioni C, Cani A, Martelli AM, et al. Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation. Oncotarget. 2014 Oct 30;5(20):10034-47. PMID: 25296981.

Custom Order

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