• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Transactivator of Transcription Peptide (2-4)

Transactivator of Transcription Peptide (2-4)

Product ID T0077
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $122.90 In stock
1 mg $209.50 In stock
2.5 mg $368.20 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Transactivator of transcription (TAT) protein is produced by HIV-1 and is involved in the induction of HIV-associated neurologic disorders (HAND). TAT is a neurotoxin that infects neurons, which HIV is unable to do. In neurons, TAT increases the number of inhibitory synapses and decreases the number of excitatory synapses in a Ca2+-dependent manner. TAT also activates microglia and other myeloid cells, disrupting cytokine/chemokine homeostasis and inducing neuroinflammation. This peptide sequence (YGRKKRRQRRRGYGRKKRRQRRRG) represents two back-to-back protein transduction (cell-penetrating) domains of TAT.

Product Info

Purity

≥95%

Formula

C132H240N66O29

Formula Wt.

3215.81

Synonym

TAT 2-4, TAT peptide, YGRKKRRQRRRGYGRKKRRQRRRG

Solubility

Soluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T0077 MSDS PDF

Info Sheet

T0077 Info Sheet PDF

References

Hargus NJ, Thayer SA. Human immunodeficiency virus-1 Tat protein increases the number of inhibitory synapses between hippocampal neurons in culture. J Neurosci. 2013 Nov 6;33(45):17908-20. PMID: 24198379.

Bethel-Brown C, Yao H, Callen S, et al. HIV-1 Tat-mediated induction of platelet-derived growth factor in astrocytes: role of early growth response gene 1. J Immunol. 2011 Apr 1;186(7):4119-29. PMID: 21368226.

Lu SM, Tremblay MÈ, King IL, et al. HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PLoS One. 2011;6(9):e23915. PMID: 21912650.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D3200

    Diacetoxyscirpenol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%
  • T5608

    α-Tocotrienol

    Antioxidant, vitamin E derivative found in vege...

    ≥98%
  • A0964

    Adrenocorticotropic Hormone (1-13), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • D1849

    4′-Demethylepipodophyllotoxin

    Podophyllotoxin derivative found in Podophyllum...

    ≥98%
  • P7628

    Parathyroid Hormone-Related Protein (1-34), human/rat

    Endogenous peptide hormone, increases extracell...

    ≥95%
  • T3040

    Thienylpentyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • I5210

    INCB018424

    JAK1/2 inhibitor.

    ≥98%
  • G0244

    alpha-Galactosylceramide

    Synthetic glycolipid found in Agelas mauritaniu...

    ≥96%
  • D3229

    7,8-Dihydrokawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • K0030

    Kahweol

    Diterpene found in coffee beans.

    ≥97%
  • K9600

    KY-02111

    Wnt signaling inhibitor.

    ≥98%
  • V3325

    Virginiamycin M1

    Macrolide antibiotic; peptidyl transferase inhi...

    ≥97%
  • D1850

    Demethoxycurcumin

    Curcumin derivative; AMPK activator, STAT3 and ...

    ≥98%
  • M9356

    Myomodulin

    Proton pump inhibitor

    ≥95%
  • J6400

    (+)-JQ-1

    Triazolothienodiazepine; BRD inhibitor.

    ≥99%
  • T3357

    Tioconazole

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • M1874

    3-Methyladenine

    Nucleobase (adenine) analog; DNA polymerase inh...

    ≥98%
  • M1752

    Men 10376

    Peptide; NK2 antagonist.

    ≥95%
  • C8069

    Curcumin

    Diarylheptanoid found in Zingiberaceae.

    ≥97% curcuminoid content
  • T1030

    N-Des-2-methylpropan-2-ol Docetaxel

    N-Des-2-methylpropan-2-ol Docetaxel is an impur...

    ≥90%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only