LKT Labs

Biochemicals for Life Science Research

Tuftsin

Tuftsin

Product ID T8020
Cas No. 9063-57-4
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $81.70 In stock
10 mg $138.90 In stock
25 mg $245.30 In stock
Bulk Quote

Quicklinks

Description

Tuftsin is a tetrapeptide that binds the neuropilin-1 (Nrp1) receptor, modulating TGF-β, cGMP, and Ca2+ signaling. Tuftsin is derived from the Fc region of IgG. Tuftsin exhibits immunomodulatory activity, inducing leukocytes to become cytotoxic effector cells and stimulating phagocytosis in macrophages and microglia in cellular models. Tuftsin also displays anticancer chemotherapeutic benefit, enhancing the effects of co-administered chemotherapeutic compounds. In animal models, tuftsin also inhibits withdrawal-associated behaviors.

Product Info

Cas No.

9063-57-4
Purity

≥95%
Formula

C21H40N8O6
Formula Wt.

500.6
IUPAC Name

(2S)-2-[[(2S)-1-[6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Solubility

Soluble in water, DMSO.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T8020 MSDS PDF
Info Sheet

T8020 Info Sheet PDF

References

Nissen JC, Selwood DL, Tsirka SE. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neurochem. 2013 Nov;127(3):394-402. PMID: 24033337.

Aronowski J, Wleklik M, Gumulka SW, et al. Modification of morphine withdrawal: effect of tuftsin, [Lys4]-tuftsinyltuftsin, tetrapeptide fragment (1-4) of substance P and its amide. Life Sci. 1985 Oct 28;37(17):1649-53. PMID: 2414628.

Nishioka K, Babcock GF, Phillips JH, et al. Antitumor effect of tuftsin. Mol Cell Biochem. 1981 Dec 4;41:13-8. PMID: 6895773.

Stabinsky Y, Bar-Shavit Z, Fridkin M, et al. On the mechanism of action of the phagocytosis-stimulating peptide tuftsin. Mol Cell Biochem. 1980 Apr 18;30(2):71-7. PMID: 6247642.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E846184

    Everolimus EP Impurity B

    Everolimus impurity

    ≥96% (mix of E/Z)
  • K2412

    KGDS

    Synthetic peptide, fibrinogen derivative; glyco...

    ≥95%
  • B4248

    BKM120

    PI3K inhibitor, microtubule polymerization inhi...

    ≥98%
  • J0240

    JAK2 Inhibitor V

    JAK2 inhibitor.

    ≥98%
  • P7060

    Protocatechuic Acid Ethyl Ester

    Dihydroxyphenolic acid found in cruciferous veg...

    ≥98%
  • C8502

    CV-70

    1,8-Diaza-anthracene-tetrone; JNK and ERK5 inhi...

    ≥70%
  • D0263

    Dapoxetine Hydrochloride

    SERT inhibitor, potential voltage-gated K+ chan...

    ≥99%
  • H9815

    25-Hydroxyvitamin D3

    Vitamin D, calcitriol prodrug; VDR agonist.

    ≥98%
  • B5044

    BML-277

    Arylbenzimidazole; CHK2 inhibitor.

    ≥98%
  • C4418

    Clemizole Hydrochloride

    TRPC5, NS4B, histamine H1 inhibitor.

    ≥98%
  • I5752

    Ionomycin, Free Acid

    Polyether Ca2+ ionophore.

    ≥98%, TLC, HPLC
  • N7200

    NS-11394

    GABA-A α5/3/2 positive modulator.

    ≥98%
  • S8147

    Sulindac Sulfide

    NSAID; COX-1/2 and PDE inhibitor.

    ≥98%
  • N7209

    NSC-207895

    Benzofuroxan derivative; MDMX inhibitor.

    ≥98%
  • S7970

    Strontium Ranelate

    Bone deterioration inhibitor, potential CaR ago...

    ≥98%
  • G4596

    Glycidamide

    Epoxide metabolite of acrylamide, induces DNA a...

    ≥98%
  • D3351

    4-Dimethylaminopyridine

    Acyl transfer catalyst, involved in peptide syn...

    ≥98%
  • H1657

    Heparin-binding Peptide

    Peptide, binds heparin.

    ≥95%
  • B3280

    Bis(salicyl) Fumarate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥98%
  • X0384

    XAV-939

    Tankyrase inhibitor.

    ≥98%