LKT Labs

Biochemicals for Life Science Research

Tuftsin

Tuftsin

Product ID T8020
Cas No. 9063-57-4
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $82.00 In stock
10 mg $139.00 In stock
25 mg $245.00 In stock
Bulk Quote

Quicklinks

Description

Tuftsin is a tetrapeptide that binds the neuropilin-1 (Nrp1) receptor, modulating TGF-β, cGMP, and Ca2+ signaling. Tuftsin is derived from the Fc region of IgG. Tuftsin exhibits immunomodulatory activity, inducing leukocytes to become cytotoxic effector cells and stimulating phagocytosis in macrophages and microglia in cellular models. Tuftsin also displays anticancer chemotherapeutic benefit, enhancing the effects of co-administered chemotherapeutic compounds. In animal models, tuftsin also inhibits withdrawal-associated behaviors.

Product Info

Cas No.

9063-57-4
Purity

≥95%
Formula

C21H40N8O6
Formula Wt.

500.6
IUPAC Name

(2S)-2-[[(2S)-1-[6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Solubility

Soluble in water, DMSO.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T8020 MSDS PDF
Info Sheet

T8020 Info Sheet PDF

References

Nissen JC, Selwood DL, Tsirka SE. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neurochem. 2013 Nov;127(3):394-402. PMID: 24033337.

Aronowski J, Wleklik M, Gumulka SW, et al. Modification of morphine withdrawal: effect of tuftsin, [Lys4]-tuftsinyltuftsin, tetrapeptide fragment (1-4) of substance P and its amide. Life Sci. 1985 Oct 28;37(17):1649-53. PMID: 2414628.

Nishioka K, Babcock GF, Phillips JH, et al. Antitumor effect of tuftsin. Mol Cell Biochem. 1981 Dec 4;41:13-8. PMID: 6895773.

Stabinsky Y, Bar-Shavit Z, Fridkin M, et al. On the mechanism of action of the phagocytosis-stimulating peptide tuftsin. Mol Cell Biochem. 1980 Apr 18;30(2):71-7. PMID: 6247642.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R2714

    Recombinant HCV-NS5 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • T0110

    Taxane Standard Mixture

    Mixture of taxanes.

    ≥98%
  • I0800

    IC-87114

    p110δ PI3K inhibitor.

    ≥98%
  • D564090

    7-epi-Docetaxel

    Docetaxel impurity

    ≥95%
  • Q8019

    Quetiapine Fumarate

    5-HT1A and σ1/2 agonist, 5-HT2A/2C/6/7, D1-4, ...

    ≥99%
  • L0349

    Lamotrigine

    R-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%
  • D1627

    Dehydrocostus Lactone

    Sesquiterpene lactone found in Saussurea.

    ≥98%
  • M0275

    Mastoparan 17

    Peptide, inactive mastoparan analog used to mea...

    ≥95%
  • T2970

    Thrombin Receptor Agonist Peptide

    Peptide; PAR1 agonist.

    ≥95%
  • N3478

    Nitrendipine

    Calcium channel blocker.

    ≥98%
  • P200097

    PF-06821497

    EZH2 inhibitor

    ≥99%
  • G733400

    GSK-2578215A

    Selective inhibitor of LRRK2.

    ≥98%
  • F4432

    FLI-06

    Notch inhibitor.

    ≥99%
  • A4854

    β-Amyloid Peptide (1-42), rat

    Endogenous APP peptide cleavage product, primar...

    ≥95%
  • S584780

    Sotorasib racemate

    KRAS inhibitor

    ≥99%
  • C3263

    Ciprofloxacin Hydrochloride Monohydrate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • L1786

    Levofloxacin Hydrochloride Monohydrate

    Fluoroquinolone, S-(-) isomer of ofloxacin; top...

    ≥90%
  • O9396

    Oxytetracycline

    Tetracycline; protein translation inhibitor.

    ≥96%
  • R0348

    Ramelteon

    Melatonin analog; MT1/2 agonist.

    ≥99%
  • E6997

    Erythropoietin, Human Recombinant

    Endogenous glycoprotein hormone involved in red...

    ≥97%