LKT Labs

Biochemicals for Life Science Research

Tuftsin

Tuftsin

Product ID T8020
Cas No. 9063-57-4
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $82.00 In stock
10 mg $139.00 In stock
25 mg $245.00 In stock
Bulk Quote

Quicklinks

Description

Tuftsin is a tetrapeptide that binds the neuropilin-1 (Nrp1) receptor, modulating TGF-β, cGMP, and Ca2+ signaling. Tuftsin is derived from the Fc region of IgG. Tuftsin exhibits immunomodulatory activity, inducing leukocytes to become cytotoxic effector cells and stimulating phagocytosis in macrophages and microglia in cellular models. Tuftsin also displays anticancer chemotherapeutic benefit, enhancing the effects of co-administered chemotherapeutic compounds. In animal models, tuftsin also inhibits withdrawal-associated behaviors.

Product Info

Cas No.

9063-57-4
Purity

≥95%
Formula

C21H40N8O6
Formula Wt.

500.6
IUPAC Name

(2S)-2-[[(2S)-1-[6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Solubility

Soluble in water, DMSO.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T8020 MSDS PDF
Info Sheet

T8020 Info Sheet PDF

References

Nissen JC, Selwood DL, Tsirka SE. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neurochem. 2013 Nov;127(3):394-402. PMID: 24033337.

Aronowski J, Wleklik M, Gumulka SW, et al. Modification of morphine withdrawal: effect of tuftsin, [Lys4]-tuftsinyltuftsin, tetrapeptide fragment (1-4) of substance P and its amide. Life Sci. 1985 Oct 28;37(17):1649-53. PMID: 2414628.

Nishioka K, Babcock GF, Phillips JH, et al. Antitumor effect of tuftsin. Mol Cell Biochem. 1981 Dec 4;41:13-8. PMID: 6895773.

Stabinsky Y, Bar-Shavit Z, Fridkin M, et al. On the mechanism of action of the phagocytosis-stimulating peptide tuftsin. Mol Cell Biochem. 1980 Apr 18;30(2):71-7. PMID: 6247642.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • U5232

    Uniconazole

    Triazole; gibberellin inhibitor, potential 14-Î...

    ≥98%
  • A4777

    Altiratinib

    c-MET, Tie-2, VEGFR inhibitor.

    ≥98%
  • C2957

    Cholesterol

    Endogenous sterol component of animal cell memb...

    ≥97%
  • D183740

    Desoxypipradrol

    NDRI inhibitor

    ≥98%
  • A0534

    Abiraterone

    Progesterone derivative; Cyp17A1 inhibitor.

    ≥99%
  • B3209

    Bicalutamide

    AR antagonist.

    ≥98%
  • P7608

    PTC124

    Read-through agent and nonsense mutation target...

    ≥98%
  • A4806

    Ambroxol Hydrochloride

    Expectorant.

    ≥98%
  • C1869

    Cerulenin

    Found in Cephalosporium; fatty acid synthase in...

    ≥98%
  • P1845

    Pelitinib

    EGFR inhibitor.

    ≥98%
  • P1869

    Perindopril Erbumine

    ACE inhibitor.

    ≥95%
  • A5326

    Aniracetam

    AMPA positive allosteric modulator, D2, 5-HT2A,...

    ≥98%
  • M400005

    MK-5108 Hydrochloride

    Aurora kinase A inhibitor.

    ≥98%
  • L1884

    Levosimendan

    Ca2+ sensitizer; ATP-sensitive K+ channel activ...

    ≥98%
  • A7333

    Asiaticoside

    Triterpene found in Centella, prevents melanoge...

    ≥90%
  • G0278

    Gatifloxacin Sesquihydrate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • P698583

    Prostaglandin E2

    principal metabolic product of COX-2

    ≥98%
  • S0132

    Saikosaponin A

    Triterpene saponin found in Bupleurum.

    ≥98%
  • P4560

    Proteolipid Protein (139-151)

    Immunodominant peptide fragment of PLP, used to...

    ≥95%
  • T698579

    Tropodithietic Acid

    Produced by various marine proteobacteria

    ≥99%