Tuftsin

Name: Tuftsin
SKU: T8020
Availability: InStock

Product ID T8020

Cas No. 9063-57-4

Purity ≥95%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Tuftsin is a tetrapeptide that binds the neuropilin-1 (Nrp1) receptor, modulating TGF-β, cGMP, and Ca2+ signaling. Tuftsin is derived from the Fc region of IgG. Tuftsin exhibits immunomodulatory activity, inducing leukocytes to become cytotoxic effector cells and stimulating phagocytosis in macrophages and microglia in cellular models. Tuftsin also displays anticancer chemotherapeutic benefit, enhancing the effects of co-administered chemotherapeutic compounds. In animal models, tuftsin also inhibits withdrawal-associated behaviors.

Product Info

Cas No.	9063-57-4
Purity	≥95%
Formula	C₂₁H₄₀N₈O₆
Formula Wt.	500.6
IUPAC Name	(2S)-2-[[(2S)-1-[6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Solubility	Soluble in water, DMSO.
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	T8020 MSDS PDF
Info Sheet	T8020 Info Sheet PDF

References

Nissen JC, Selwood DL, Tsirka SE. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neurochem. 2013 Nov;127(3):394-402. PMID: 24033337.

Aronowski J, Wleklik M, Gumulka SW, et al. Modification of morphine withdrawal: effect of tuftsin, [Lys4]-tuftsinyltuftsin, tetrapeptide fragment (1-4) of substance P and its amide. Life Sci. 1985 Oct 28;37(17):1649-53. PMID: 2414628.

Nishioka K, Babcock GF, Phillips JH, et al. Antitumor effect of tuftsin. Mol Cell Biochem. 1981 Dec 4;41:13-8. PMID: 6895773.

Stabinsky Y, Bar-Shavit Z, Fridkin M, et al. On the mechanism of action of the phagocytosis-stimulating peptide tuftsin. Mol Cell Biochem. 1980 Apr 18;30(2):71-7. PMID: 6247642.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Email
This field is for validation purposes and should be left unchanged.

Tuftsin

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Angiotensin II (3-8), human

ZLN005

VX-702

AZD-1480

Ethisterone

Pimecrolimus

Isobavachalcone

Fumitremorgin C

LMK-235

5-(Methylsulfinyl)pentyl Nitrile

10-Hydroxycamptothecin

α-Calcitonin Gene Related Peptide, human

Abemaciclib mesylate

Dexamethasone

Carcinoembryonic Antigen (605-613)

Tetrodotoxin Citrate

Nitisinone

BAY-1251152

Asiatic Acid, 95%

Cytochalasin C

Footer