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Tylosin is a macrolide antibiotic originally produced by Streptomyces. Like other macrolides, tylosin binds the 50S subunit of the bacterial ribosome, suppressing mitochondrial protein translation; it inhibits peptidyl transferase, preventing translocation. Tylosin displays antibacterial efficacy against most gram positive and some gram negative bacteria such as Campylobacter.
| Cas No. | 1405-54-5 |
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| Purity | ≥90% |
| Formula | C46H77NO17 • C4H6O6 |
| Formula Wt. | 1066.19 |
| Chemical Name | (R-(R*,R*))-2,3-dihydroxybutanedioate Tylosin (salt) |
| IUPAC Name | (2R,3R)-2,3-dihydroxybutanedioic acid;2-[(4R,5S,7R,9R,11E,13E,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S, 6S)-4,5-dihydroxy-4, 6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl] oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3, 4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2, 10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde |
| Synonym | Pharmasin |
| Solubility | Soluble in water. |
| Appearance | White to buff powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
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| Info Sheet |
Liu M, Douthwaite S. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14658-63. PMID: 12417742.
Zalacain M, Cundliffe E. Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. J Bacteriol. 1989 Aug;171(8):4254-60. PMID: 2753855.