LKT Labs

Biochemicals for Life Science Research

[Tyr8]-Bradykinin

[Tyr8]-Bradykinin

Product ID B6811
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $114.30 Please Inquire
10 mg $196.20 Please Inquire
50 mg $343.60 Please Inquire
Bulk Quote

Quicklinks

Description

Bradykinin is a peptide that exhibits natriuretic, antioxidative, vasodilatory, and pro-angiogenic activities. Bradykinin stimulates bradykinin receptors and increases PLC activity, decreasing ENaC open probability, inhibiting distal nephron Na+ transport, and inducing natriuresis. In vitro, bradykinin decreases H2O2-induced senescence, increases activity of superoxide dismutase (SOD), and suppresses DNA damage, ROS production, and NADPH oxidase activity. Additionally, bradykinin increases expression of VEGF and promotes tube formation in prostate cancer cells.

Product Info

Purity

≥95%
Formula

C50H73N15O12
Formula Wt.

1076.23
Solubility

Soluble in water, acid.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B6811 MSDS PDF
Info Sheet

B6811 Info Sheet PDF

References

Mamenko M, Zaika O, Pochynyuk O. Direct regulation of ENaC by bradykinin in the distal nephron. Implications for renal sodium handling. Curr Opin Nephrol Hypertens. 2014 Mar;23(2):122-9. PMID: 24378775.

Yu HS, Wang SW, Chang AC, et al. Bradykinin promotes vascular endothelial growth factor expression and increases angiogenesis in human prostate cancer cells. Biochem Pharmacol. 2014 Jan 15;87(2):243-53. PMID: 24225154.

Dong R, Xu X, Li G, et al. Bradykinin inhibits oxidative stress-induced cardiomyocytes senescence via regulating redox state. PLoS One. 2013 Oct 25;8(10):e77034. PMID: 24204728.

Feher A, Cassuto J, Szabo A, et al. Increased tissue angiotensin-converting enzyme activity impairs bradykinin-induced dilation of coronary arterioles in obesity. Circ J. 2013;77(7):1867-76. PMID: 23603844.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E2002

    Efaroxan Hydrochloride

    α2-adrenergic and imidazoline-1 antagonist, AT...

    ≥99%
  • C3578

    L-Citrulline

    Byproduct of L-arginine metabolism found in wat...

    ≥98%
  • E6896

    Erysolin

    ITC found in cruciferous vegetables, analog of ...

    ≥97%
  • E6994

    Erythromycin

    Macrolide; protein translation inhibitor, mamma...

    ≥94%
  • V9200

    VX-950

    NS3/4A serine protease inhibitor.

    ≥98%
  • C6955

    Cromolyn Sodium

    Mast cell destabilizer; potential TRP antagonis...

    ≥99%
  • B5044

    BML-277

    Arylbenzimidazole; CHK2 inhibitor.

    ≥98%
  • I530280

    INH1

    Hec1/Nek2 mitotic pathway inhibitor

    ≥98%
  • S8246

    Sulfadimethoxine

    Sulfonamide; folic acid synthesis inhibitor.

    ≥98%
  • D1872

    Des(benzylpyridyl) Atazanavir

    Atazanavir metabolite; HIV protease inhibitor.<...

    ≥98%
  • T0253

    Tangeretin

    Polymethoxy flavonoid found in citrus fruits.

    ≥98%
  • A0822

    N-Acetyl-S-(N-methylsulfinylbutylthiocarbamoyl)-L-cysteine

    Sulforaphane-cysteine conjugate.

    ≥98%
  • A4544

    Allyl Disulfide

    Organosulfur found in garlic.

    ≥98%
  • E7758

    Etomidate

    GABA-A agonist.

    ≥99%
  • Z5744

    Zoledronic Acid Hydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%
  • W0247

    Walrycin B

    Walrycin response regulator inhibitor.

    ≥98%
  • A5030

    4-Aminophenylphosphate Monosodium

    Alkaline phosphatase substrate used to quantify...

    ≥97%
  • O1200

    Odanacatib

    Cathepsin K inhibitor.

    ≥99%
  • Z1602

    Zearalenone

    Mycotoxin produced by Fusarium; ER agonist.

    ≥98%
  • H800010

    HU 308

    Cannabinoid receptor 2 selective agonist.

    ≥98%