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Tyrphostin AG490

Tyrphostin AG490

Product ID T9969
Cas No. 133550-30-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $134.60 In stock
10 mg $230.10 In stock
25 mg $513.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tyrphostin AG490 inhibits JAK2 and exhibits anti-diabetic, anti-atherosclerotic, immunosuppressive, and anticancer activities. Tyrphostin AG490 inhibits joint inflammation in vivo by suppressing activation of STAT3, production of TNF-α and RANKL, and differentiation of osteoclasts. Tyrphostin AG490 also induces programmed cell death and inhibits invasion and adhesion of leukemia cells. In animal models of atherosclerosis, tyrphostin AG490 decreases activity and expression of Nox and levels of CD68, decreasing the formation of atherosclerotic lesions. Additionally, tyrphostin AG490 increases expression of PPARγ and decreases blood glucose levels in vivo, preventing the onset of autoimmune type 1 diabetes. This compound also inhibits expression of MCP-1, IFNγ, and MHC class II, decreases infiltration of T cells and macrophages, and suppresses deposition of IgG in animal models of lupus nephritis. Tyrphostin AG490 may also inhibit EGFR.

Product Info

Cas No.

133550-30-8

Purity

≥98%

Formula

C17H14N2O3

Formula Wt.

294.31

Chemical Name

N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide

IUPAC Name

N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide

Synonym

Tyrphostin B42

Melting Point

215-216.5°C

Solubility

Soluble in DMSO.

Appearance

Greenish-yellow microcrystalline powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

T9969 MSDS PDF

Info Sheet

T9969 Info Sheet PDF

Brochures

JAK/STAT Flyer

References

Gyurkovska V, Stefanova T, Dimitrova P, et al. Tyrosine Kinase Inhibitor Tyrphostin AG490 Retards Chronic Joint Inflammation in Mice. Inflammation. 2014 Aug;37(4):995-1005. PMID: 24473905.

Davoodi-Semiromi A, Hassanzadeh A, Wasserfall CH, et al. Tyrphostin AG490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor. J Clin Immunol. 2012 Oct;32(5):1038-47. PMID: 22661285.

Fenyo IM, Florea IC, Raicu M, et al. Tyrphostin AG490 reduces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice. Vascul Pharmacol. 2011 Mar-Jun;54(3-6):100-6. PMID: 21457788.

Wang S, Yang N, Zhang L, et al. Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice. Lupus. 2010 Sep;19(10):1171-80. PMID: 20501525.

Caceres-Cortes JR. A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490. Anticancer Agents Med Chem. 2008 Oct;8(7):717-22. PMID: 18855573.

Custom Order

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