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Verubecestat

Verubecestat

Product ID V182705
Cas No. 1286770-55-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $99.80 In stock
25 mg $341.30 In stock
100 mg $997.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Verubecestat is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor. Verubecestat was found to reduce amyloid in plasma, cerebral spinal fluid, and brains in several animal models. However, development of verubecestat as a treatment was halted when it was shown to have no impact on slowing the progression of Alzheimer’s disease.

Product Info

Cas No.

1286770-55-5

Purity

≥98%

Formula

C17H17F2N5O3S

Formula Wt.

409.41

Chemical Name

N-(3-(3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoro-2-pyridinecarboxamide

IUPAC Name

N-[3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide

Synonym

MK-8931, MK8931

Solubility

DMSO:81 mg/mL (197.84 mM); Ethanol:41 mg/mL (100.14 mM); Water:Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V182705 MSDS PDF

Info Sheet

V182705 Info Sheet PDF

References

Villarreal S, Zhao F, Hyde LA, et al. Chronic verubecestat treatment suppresses amyloid accumulation in advanced aged Tg2576-AbPPswe mice without inducing microhemorrhage. J Alzheimers Dis. 2017;59(4):1393-1413. PMID: 28800329.

Kennedy ME, Stamford AW, Chen X, et al. The BACE1 inhibitor verubecestat (MK-8931) reduces CNS beta-amyloid in animal models and in Alzheimer’s disease patients. Sci Transl Med. 2016 Nov 2;8(363):363ra150. PMID: 27807285.

Oblak A, Cope Z, Quinney S, et al. Prophylactic evaluation of verubecestat on disease-and symptom-modifying effects in 5XFAD mice. Alzheimers Dement (N Y). 2022 Jul 14;8(1):e12317. PMID: 35846156.

Watamura N, Sato K, Shiihashi G, et al. An isogenic panel of App knock-in mouse models: profiling beta-secretase inhibition and endosomal abnormalities. Sci Adv. 2022 Jun 10;8(23):eabm6155. PMID: 35675411.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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  • This field is for validation purposes and should be left unchanged.

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