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Vortioxetine

Vortioxetine

Product ID V5870
Cas No. 508233-74-7
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $68.30 In stock
10 mg $94.50 In stock
25 mg $173.30 In stock
100 mg $262.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Vortioxetine exhibits neuromodulatory, antidepressant, anxiolytic, and cognition enhancing activities. Vortioxetine modulates serotonin levels in the brain by inhibiting the serotonin transporter (SERT) and 5-HT3A/7 receptors, acting as a partial agonist at the 5-HT1B receptor, and acting as a full agonist at the 5-HT1A receptor. Vortioxetine also shows some agonist activity at β1-adrenergic receptors, although this is likely not related to its beneficial activities. In addition to its mood-modulating action, this compound also improves memory performance and reduces 5-HT-depletion-induced memory deficits in object recognition and Y-maze spontaneous alternation tests.

Product Info

Cas No.

508233-74-7

Purity

≥99%

Formula

C18H22N2S

Formula Wt.

298.45

Chemical Name

1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine

IUPAC Name

1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine

Synonym

Lu AA21004

Appearance

Off-white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V5870 MSDS PDF

Info Sheet

V5870 Info Sheet PDF

References

du Jardin KG, Jensen JB, Sanchez C, et al. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. Eur Neuropsychopharmacol. 2013 Aug 2. [Epub ahead of print]. PMID: 23916504.

Henigsberg N, Mahableshwarkar AR, Jacobsen P, et al. A randomized, double-blind, placebo-controlled 8-week trial of the efficacy and tolerability of multiple doses of Lu AA21004 in adults with major depressive disorder. J Clin Psychiatry. 2012 Jul;73(7):953-9. PMID: 22901346.

Bang-Andersen B, Ruhland T, Jørgensen M, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21. PMID: 21486038.

Custom Order

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