• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Vortioxetine

Vortioxetine

Product ID V5870
Cas No. 508233-74-7
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $68.30 In stock
10 mg $94.50 In stock
25 mg $173.30 In stock
100 mg $262.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Vortioxetine exhibits neuromodulatory, antidepressant, anxiolytic, and cognition enhancing activities. Vortioxetine modulates serotonin levels in the brain by inhibiting the serotonin transporter (SERT) and 5-HT3A/7 receptors, acting as a partial agonist at the 5-HT1B receptor, and acting as a full agonist at the 5-HT1A receptor. Vortioxetine also shows some agonist activity at β1-adrenergic receptors, although this is likely not related to its beneficial activities. In addition to its mood-modulating action, this compound also improves memory performance and reduces 5-HT-depletion-induced memory deficits in object recognition and Y-maze spontaneous alternation tests.

Product Info

Cas No.

508233-74-7

Purity

≥99%

Formula

C18H22N2S

Formula Wt.

298.45

Chemical Name

1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine

IUPAC Name

1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine

Synonym

Lu AA21004

Appearance

Off-white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V5870 MSDS PDF

Info Sheet

V5870 Info Sheet PDF

References

du Jardin KG, Jensen JB, Sanchez C, et al. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. Eur Neuropsychopharmacol. 2013 Aug 2. [Epub ahead of print]. PMID: 23916504.

Henigsberg N, Mahableshwarkar AR, Jacobsen P, et al. A randomized, double-blind, placebo-controlled 8-week trial of the efficacy and tolerability of multiple doses of Lu AA21004 in adults with major depressive disorder. J Clin Psychiatry. 2012 Jul;73(7):953-9. PMID: 22901346.

Bang-Andersen B, Ruhland T, Jørgensen M, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21. PMID: 21486038.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M568266

    Mogroside IIIe

    Triterpenoid

    ≥98%
  • C4646

    Clofarabine

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • O7218

    Oseltamivir Phosphate

    Viral neuraminidase inhibitor, potential MAO-A ...

    ≥98%
  • G0179

    Gastrin-1, rat

    Endogenous peptide hormone; CCK2 agonist, indir...

    ≥95%
  • C3374

    Cisplatin

    Pt-based DNA cross-linker.

    ≥99%
  • A9708

    AZD-1208

    Pim-1 inhibitor.

    ≥98%
  • G1849

    Gemifloxacin Mesylate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • A6058

    Apoptosis Activator 2

    Apoptosis inducing agent.

    ≥98%
  • K1678

    Ketanserin

    5-HT2A antagonist, potential α1-adrenergic ant...

    ≥97%
  • A4547

    Alloxan Monohydrate

    Pyrimidine, glucose analog, used to induce diab...

    ≥98%
  • P3462

    Piperacillin

    β-lactam; penicillin binding protein inhibitor...

    ≥95%
  • M324083

    Micafungin

    Echinocandin

    ≥95%
  • T1656

    Tenoxicam Impurity B

    Tenoxicam impurity

    ≥98%
  • G1308

    GDC-0032

    PI3K inhibitor.

    ≥98%
  • A4803

    Amantadine Sulfate

    Viral M2 proton channel blocker, MAO-A, NET, NM...

    ≥98%
  • R2510

    RGD-4C

    Peptide, used to deliver conjugated drugs to ce...

    ≥95%
  • S8014

    Substance P, Free Acid

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • B5753

    Bongkrekic Acid

    Respiratory toxin, mitochondrial permeability t...

    ≥95%
  • A4940

    6-Aminonicotinamide

    G6PDH inhibitor.

    ≥98%
  • L1682

    Levamisole Hydrochloride

    Imidazothiazole; alkaline phosphatase inhibitor...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only