• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Vortioxetine

Vortioxetine

Product ID V5870
Cas No. 508233-74-7
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $68.30 In stock
10 mg $94.50 In stock
25 mg $173.30 In stock
100 mg $262.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Vortioxetine exhibits neuromodulatory, antidepressant, anxiolytic, and cognition enhancing activities. Vortioxetine modulates serotonin levels in the brain by inhibiting the serotonin transporter (SERT) and 5-HT3A/7 receptors, acting as a partial agonist at the 5-HT1B receptor, and acting as a full agonist at the 5-HT1A receptor. Vortioxetine also shows some agonist activity at β1-adrenergic receptors, although this is likely not related to its beneficial activities. In addition to its mood-modulating action, this compound also improves memory performance and reduces 5-HT-depletion-induced memory deficits in object recognition and Y-maze spontaneous alternation tests.

Product Info

Cas No.

508233-74-7

Purity

≥99%

Formula

C18H22N2S

Formula Wt.

298.45

Chemical Name

1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine

IUPAC Name

1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine

Synonym

Lu AA21004

Appearance

Off-white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V5870 MSDS PDF

Info Sheet

V5870 Info Sheet PDF

References

du Jardin KG, Jensen JB, Sanchez C, et al. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. Eur Neuropsychopharmacol. 2013 Aug 2. [Epub ahead of print]. PMID: 23916504.

Henigsberg N, Mahableshwarkar AR, Jacobsen P, et al. A randomized, double-blind, placebo-controlled 8-week trial of the efficacy and tolerability of multiple doses of Lu AA21004 in adults with major depressive disorder. J Clin Psychiatry. 2012 Jul;73(7):953-9. PMID: 22901346.

Bang-Andersen B, Ruhland T, Jørgensen M, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21. PMID: 21486038.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B4517

    Bleomycin A5 Hydrochloride

    Glycopeptide, induces DNA strand breaks.

    ≥90%
  • E7578

    Estramustine

    Nitrogen mustard and estradiol derivative; micr...

    ≥97%
  • G4481

    Glucagon-like Peptide I Amide (7-36), human

    Endogenous peptide hormone, GLP-1 fragment, inv...

    ≥95%
  • N0205

    Nabumetone

    1-Naphthalenacetic acid derivative, NSAID; COX-...

    ≥98%
  • B8074

    3-tert-Butyl-5-Methoxy-1,2-quinone

    BHA derivative.

    ≥98%
  • L1852

    Lenalidomide

    Thalidomide derivative; cereblon and TNF-α inh...

    ≥98%
  • U698576

    Urolithin B

    Ellagic acid derivative produced by gut microfl...

    ≥99%
  • A4578

    Altretamine

    DNA alkylator.

    ≥98%
  • B8278

    Butoconazole Nitrate

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • N1978

    Neurokinin B

    Neuromodulator, biomarker

    ≥95%
  • D023721

    Dasatinib

    Multikinase inhibitor.

    ≥99%
  • C5972

    Corynoline

    Alkaloid compound originally found in Corydalis...

    ≥98%
  • B3458

    Biopterin

    Endogenous pterin coenzyme required for release...

    ≥98%
  • P4132

    PKI-402

    p110α PI3K and mTOR inhibitor.

    ≥98%
  • A6922

    Arformoterol Tartrate

    R,R enantiomer of formoterol; β2-adrenergic an...

    ≥98%
  • S6131

    N,N-Dimethyl-Sphingosine

    PP2A activator, Sphk1 and PKC inhibitor.

    ≥98%
  • I7302

    Isatin

    Indole derivative found in Isatis, Calanthe, an...

    ≥97%
  • M3353

    Minocycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥98%
  • N5605

    Nobiletin

    Polymethoxylated flavone found in citrus fruits...

    ≥97%
  • L8377

    Luteolin

    Flavonoid found in various plant sources; DAT a...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only