Description
WIN 55,212-2 (WIN)is a potent, non-selective synthetic cannabinoid agonist. It shows activity in a variety of disease states. Recent work demonstrates the ability of WIN as a pain analgesic, anti-cancer and anti-Alzheimer’s compound. In studies using colon carcinoma cell lines, WIN decreases cell proliferation of colon cancer cells. Additionally WIN down-regulated protein phosphatase 2A, a different mechanism than other cannabinoid agonists. WIN also decreases the effects of Amyloid 1-42 effects on primary mouse astrocyte cell culture. WIN inhibits the over-expression of interleukin-1 and tumor necrosis factor-, common signs of A over expression. Additionally, in a murine pain model, WIN decreased the response to pain stiumuli in mouse models of cancer pain.