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Wortmannin is a steroid metabolite initially produced by fungi in the Penicillum genus. Wortmannin inhibits PI3K, mTOR, DNA-PK, PI4K, MLCK, MAPKs, and polo-like kinases (PLKs). In vivo, wortmannin inhibits activation of Akt and AMPK and decreases translocation of GLUT4, suppressing glucose uptake. Wortmannin also inhibits insulin-induced skeletal myoblast differentiation.
| Cas No. | 19545-26-7 |
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| Purity | ≥97% |
| Formula | C23H24O8 |
| Formula Wt. | 428.43 |
| Chemical Name | (1S,6bR,9aS,11R,11bR)-11-(Acetyloxy)-1,6b,7,8,9a,10,-11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]ideno[4,5-h]-2-benzopyran-3,6,9- trione |
| IUPAC Name | [(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate |
| Synonym | Wartmannin, KY 12420, SL-2052 |
| Melting Point | 240°C |
| Solubility | Soluble in methanol and DMSO. |
| Appearance | White Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zhou X, Zhao Y, Xu L, et al. Wortmannin and U0126 inhibit the promoting effect of insulin on differentiation of skeletal myoblasts in rats. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jul;30(7):717-20. PMID: 25001936.
Ji L, Zhang X, Liu W, et al. AMPK-regulated and Akt-dependent enhancement of glucose uptake is essential in ischemic preconditioning-alleviated reperfusion injury. PLoS One. 2013 Jul 26;8(7):e69910. PMID: 23922853.
Zaika O, Lara LS, Gamper N, et al. Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels. J Physiol. 2006 Aug 15;575(Pt 1):49-67. PMID: 16777936.