LKT Labs

Biochemicals for Life Science Research

Chelerythrine Chloride

Chelerythrine Chloride

Product ID C2818
Cas No. 3895-92-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $95.00 In stock
5 mg $260.00 In stock
25 mg $714.00 Please Inquire
Bulk Quote

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Description

Chelerythrine is a benzophenanthridine alkaloid found in Chelidonium and Zanthoxylum that exhibits anti-inflammatory and anticancer activities. Chelerythrine inhibits PKC and Na+/K+ ATPases. In LPS-stimulated animal models, chelerythrine decreases levels of TNF-α, IL-6, and myeloperoxidase. In hepatoma cells, this compound decreases the mitochondrial membrane potential, increases release of cytochrome C, stimulates cleavage of PARP, alters the Bax/Bcl-xl ratio, and induces apoptosis.

Product Info

Cas No.

3895-92-9
Purity

≥98%
Formula

C21H18ClNO4
Formula Wt.

383.82
Chemical Name

1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium

IUPAC Name

1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5, 6-c]phenanthridin-12-ium;chloride
Synonym

Toddaline
Melting Point

207°C
Solubility

Soluble in DMSO.

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

C2818 MSDS PDF
Info Sheet

C2818 Info Sheet PDF

References

Niu X, Mu Q, Li W, et al. Protective Effects of Chelerythrine Against Lipopolysaccharide-Induced Endotoxic Shock in Mice. Inflammation. 2014 Jun 14. [Epub ahead of print]. PMID: 24928629.

Dorney KM, Sizemore IE, Alqahtani T, et al. Surface-enhanced Raman spectroscopy (SERS) tracking of chelerythrine, a Na(+)/K(+) pump inhibitor, into cytosol and plasma membrane fractions of human lens epithelial cell cultures. Cell Physiol Biochem. 2013;32(7):146-56. PMID: 24429821.

Zhang ZF, Guo Y, Zhang JB, et al. Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell. Arch Pharm Res. 2011 May;34(5):791-800. PMID: 21656365.

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