LKT Labs

Biochemicals for Life Science Research

Dihydromethysticin

Dihydromethysticin

Product ID D3227
Cas No. 19902-91-1
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $147.20 In stock
5 mg $280.40 In stock
10 mg $433.00 In stock
Bulk Quote

Quicklinks

Description

Dihydromethysticin is a kavalactone originally found in Piper methysticum (kava plant) that exhibits antifungal, antiepileptic/anticonvulsant, neuroprotective, anticancer, and chemopreventive activities. This compound displays antimicrobial efficacy against species of Fusarium, Trichoderma, and Colletotrichum. Dihydromethysticin also binds receptor site 2 and inhibits voltage-gated Na+ channels; it inhibits L-type voltage-gated Ca2+ channels as well. In vivo, dihydromethysticin inhibits the formation of NNK-induced tumors and, separately, protects against cerebral ischemia-induced damage.

Product Info

Cas No.

19902-91-1
Purity

≥97%
Formula

C15H16O5
Formula Wt.

276.28
IUPAC Name

(2S)-2-[2-(1,3-benzodioxol-5-yl)ethyl]-4-methoxy-2,3-dihydropyran-6-one
Synonym

2H-Pyran-2-one,6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-, (S)-, 7,8-Dihydromethysticin

Appearance

White crystalline powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

D3227 MSDS PDF
Info Sheet

D3227 Info Sheet PDF

References

Narayanapillai SC, Balbo S, Leitzman P, et al. Dihydromethysticin (DHM) from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice. Carcinogenesis. 2014 Jul 22. [Epub ahead of print]. PMID: 25053626.

Xuan TD, Elzaawely AA, Fukuta M, et al. Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). J Agric Food Chem. 2006 Feb 8;54(3):720-5. PMID: 16448174.

Friese J, Gleitz J. Kavain, dihydrokavain, and dihydromethysticin non-competitively inhibit the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to receptor site 2 of voltage-gated Na+ channels. Planta Med. 1998 Jun;64(5):458-9. PMID: 9690349.

Backhauss C, Krieglstein J. Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. Eur J Pharmacol. 1992 May 14;215(2-3):265-9. PMID: 1396990.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M1978

    S-(+)-Methoprene

    Juvenille insect growth hormone analog.

    ≥95%
  • G1853

    Genipin

    Iridoid glycoside found in Gardinia jasminoides...

    ≥99%
  • A0920

    N-Acetyl-S-(N′-phenethylthiocarbamoyl)-L-cysteine

    N-acetyl cysteine conjugate of phenethylisothio...

    ≥95%
  • T6930

    Triclosan Methyl Ether

    Diarylether; bacterial ENR binder, fatty acid s...

    ≥99%
  • C2900

    CH5424802

    ALK inhibitor.

    ≥99%
  • R2811

    Recombinant HIV-1 gp-41

    Recombinant HIV glycoprotein antigen fragment.<...

    ≥95%
  • C2943

    Chlorogenic Acid (from Eucommia)

    Polyphenol derivative of caffeic acid found in ...

    ≥98%
  • C9662

    Cyproterone Acetate

    Steroid; AR antagonist.

    ≥98%
  • F4532

    Flibanserin

    5-HT1A agonist, 5-HT2A antagonist.

    ≥97%
  • L0350

    Lamivudine

    Nucleoside (thymidine) analog; RT inhibitor.

    ≥99%
  • A2077

    Afatinib

    EGFR inhibitor.

    ≥98%
  • A0960

    Adrenocorticotropic Hormone (1-39), human

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • C1718

    Cepharanthine, 95%

    Alkaloid found in Stephania.

    ≥95%
  • G7241

    GSK-461364

    PLK1 inhibitor.

    ≥99%
  • M568268

    Mogroside IV

    Triterpenoid

    ≥98%
  • P1765

    Peptide Standard 1

    For use in amino acid analysis.

    ≥95%
  • C291342

    CHIR-99021

    GSK3 inhibitor.

    ≥98%
  • G1200

    GDC-0068

    Akt inhibitor.

    ≥98%
  • J8800

    JW55

    TNKS1/2 inhibitor.

    ≥98%
  • S1845

    L-(+)-Selenomethionine

    Naturally occurring amino acid found in grains,...

    ≥98%