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Glimepiride is a second generation sulfonylurea that exhibits anti-diabetic activity. Glimepiride inhibits ATP-dependent K+ channels in β cells, forcing cells to remain depolarized, increasing Ca2+ influx and insulin secretion. Glimepiride also exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-β (Aβ) in neurons in a PPARγ-dependent manner.
| Cas No. | 93479-97-1 |
|---|---|
| Purity | ≥98% |
| Formula | C24H34N4O5S |
| Formula Wt. | 490.62 |
| Chemical Name | 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide |
| IUPAC Name | 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl] ethyl]-5-oxo-2H-pyrrole-1-carboxamide |
| Synonym | HOE-490, Amarel |
| Melting Point | 212-215°C |
| Solubility | Soluble in DMSO (25mg/mL). |
| Appearance | White or almost white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Liu F, Wang Y, Yan M, et al. Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons. Neurosci Lett. 2013 Dec 17;557 Pt B:90-4. PMID: 24184877.
Bashir MI, Pathan MF, Raza SA, et al. Role of oral hypoglycemic agents in the management of type 2 diabetes mellitus during Ramadan. Indian J Endocrinol Metab. 2012 Jul;16(4):503-7. PMID: 22837904.
Abdelmoneim AS, Hasenbank SE, Seubert JM, et al. Variations in tissue selectivity amongst insulin secretagogues: a systematic review. Diabetes Obes Metab. 2012 Feb;14(2):130-8. PMID: 21923736.