LKT Labs

Biochemicals for Life Science Research

Maprotiline Hydrochloride

Product ID M0262
Cas No. 10347-81-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $58.20 In stock
5 g $233.60 In stock
Bulk Quote

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Description

Maprotiline is a tetracyclic antidepressant that also exhibits sedative, anxiolytic, sympathomimetic, and anticancer activities. Maprotiline acts as an antagonist at norepinephrine transporters (NET), H1 histamine receptors, 5-HT2 receptors, α1-adrenergic receptors, muscarinic acetylcholine receptors (mAChRs), and L-type Ca2+ channels. Maprotiline induces caspase-mediated apoptosis in neuroblastoma cells, inhibiting cell viability in a JNK- and ERK-dependent manner. This compound also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

10347-81-6
Purity

≥98%
Formula

C20H23N • HCl
Formula Wt.

313.87
Chemical Name

N-Methyl-9.10-ethanoanthracene-9(10H)-propanamine hydrochloride
IUPAC Name

N-methyl-3-(1-tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaenyl)propan-1-amine;hydrochloride
Synonym

Deprilept, Ludiomil, Psymion
Melting Point

230-232°C

Solubility

Soluble in methanol and chloroform. Slightly soluble in water.

Appearance

A White or Almost White Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

M0262 MSDS PDF
Info Sheet

M0262 Info Sheet PDF

References

Jan CR, Su JA, Teng CC, et al. Mechanism of maprotiline-induced apoptosis: role of [Ca2+](i), ERK, JNK and caspase-3 signaling pathways. Toxicology. 2013 Feb 8;304:1-12. PMID: 23219590.

Zahradník I, Minarovic I, Zahradníková A. Inhibition of the cardiac L-type calcium channel current by antidepressant drugs. J Pharmacol Exp Ther. 2008 Mar;324(3):977-84. PMID: 18048694.

Mayers AG, Baldwin DS. Antidepressants and their effect on sleep. Hum Psychopharmacol. 2005 Dec;20(8):533-59. PMID: 16229049.

Muscat R, Papp M, Willner P. Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline. Psychopharmacology (Berl). 1992;109(4):433-8. PMID: 1365858.

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