LKT Labs

Biochemicals for Life Science Research

LY-294002 Hydrochloride

LY-294002 Hydrochloride

Product ID L960002
Cas No. 934389-88-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $47.80 In stock
5 mg $102.30 In stock
25 mg $293.20 In stock
100 mg $817.60 In stock
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Description

Water soluble form of LY-294002 (L4796). LY-294002 is an inhibitor of PI3K that is used to sensitize cancer cells to other co-administered anticancer chemotherapeutics. In macrophages and monocytes, LY-294002 inhibits NF-κB activity and decreases levels of p50 NF-κB; it also inhibits LPS-induced expression of IL-10. LY-294002 prevents ruffled border formation in osteoclasts by altering the binding of acidic vacuoles with the intercellular membrane. Additionally, this compound inhibits DNA-dependent protein kinase (DPK) activity and prevents the formation of NO.

Product Info

Cas No.

934389-88-5
Purity

≥98%
Formula

C19H17NO3 • HCl
Formula Wt.

343.81
IUPAC Name

2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-one hydrochloride (1:1)
Synonym

LY294002 HCl

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L960002 MSDS PDF
Info Sheet

L960002 Info Sheet PDF

References

Avni D, Glucksam Y, Zor T. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor κB inhibition, in a PI3K-independent mechanism. Biochem Pharmacol. 2012 Jan 1;83(1):106-14. PMID: 22005520.

Salh B, Wagey R, Marotta A, et al. Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production. J Immunol. 1998 Dec 15;161(12):6947-54. PMID: 9862729.

Nakamura I, Sasaki T, Tanaka S, et al. Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts. J Cell Physiol. 1997 Aug;172(2):230-9. PMID: 9258344.

Rosenzweig KE, Youmell MB, Palayoor ST, et al. Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin Cancer Res. 1997 Jul;3(7):1149-56. PMID: 9815794.

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