• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Glycylglutamine

Glycylglutamine

Product ID G6400
Cas No. 13115-71-4
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $98.40 Please Inquire
10 mg $167.80 Please Inquire
25 mg $294.60 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Glycylglutamine (GQ) is an endogenous β-endorphin-derived dipeptide that exhibits antioxidative, cardioprotective, anti-inflammatory, and neuromodulatory activities. In animal models of burn injury, GQ decreases serum creatine kinase, lactate dehydrogenase, and lactic acid and increases serum ATP and glutathione, decreasing myocardial damage and improving cardiac contractility. In animal models of liver transplant, GQ increases levels of secretory IgA (sIgA) and decreases levels of TNF-α, improving microvilli structure and intestinal barrier function. Additionally, GQ inhibits IL-1β-induced thermogenesis and prostaglandin E2 (PGE2) production, suppressing the development of fever in vivo. In animal models of opioid use, GQ inhibits opioid-induced dopamine signaling, preventing reward and suppressing development of tolerance and withdrawal. GQ also inhibits nicotine-induced reward signaling in conditioned place preference (CPP) paradigms as well as development of nicotine withdrawal.

Product Info

Cas No.

13115-71-4

Purity

≥95%

Formula

C7H13N3O4

Formula Wt.

203.2

IUPAC Name

(2S)-5-amino-2-[(2-aminoacetyl)amino]-5-oxopentanoic acid

Synonym

GQ

Solubility

Soluble in water, acid.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G6400 MSDS PDF

Info Sheet

G6400 Info Sheet PDF

References

Zhang Y, Yan H, Lv SG, et al. Effects of glycyl-glutamine dipeptide supplementation on myocardial damage and cardiac function in rats after severe burn injury. Int J Clin Exp Pathol. 2013 Apr 15;6(5):821-30. PMID: 23638213.

Jiang JW, Ren ZG, Chen LY, et al. Enteral supplementation with glycyl-glutamine improves intestinal barrier function after liver transplantation in rats. Hepatobiliary Pancreat Dis Int. 2011 Aug;10(4):380-5. PMID: 21813386.

Basaran NF, Buyukuysal RL, Millington WR, et al. Glycyl-glutamine (beta-endorphin(30-31)) inhibits morphine-induced dopamine efflux in the nucleus accumbens. Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):467-75. PMID: 20349045.

Göktalay G, Cavun S, Levendusky MC, et al. Glycyl-glutamine inhibits nicotine conditioned place preference and withdrawal. Eur J Pharmacol. 2006 Jan 13;530(1-2):95-102. PMID: 16364288.

Resch GE, Millington WR. Inhibition of interleukin-1beta and prostaglandin E(2) thermogenesis by glycyl-glutamine, a pro-opiomelanocortin-derived peptide. Brain Res. 2001 Mar 16;894(2):316-20. PMID: 11251208.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L589940

    LOXO-101

    Inhibitor of tropomyosin kinase receptors TRKA,...

    ≥99%
  • E537331

    Enniatin Complex

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • P1917

    Phenylethyl 3-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥97%
  • B0150

    Bambuterol Hydrochloride

    β2-adrenergic agonist, BChE inhibitor.

    ≥98%
  • M4004

    MK-2461

    MET, FGFR, PDGFR inhibitor.

    ≥99%
  • A980005

    AZ-5104

    Inhibitor of EGFR.

    ≥98%
  • D564088

    10-Acetyl Docetaxel

    Docetaxel impurity

    ≥98%
  • E5221

    Endothelin-2, human

    Endogenous peptide involved in vascular contrac...

    ≥95%
  • L0251

    Laminin Peptide CDPGYIGSR

    Laminin-derived nonapeptide.

    ≥98%
  • A5284

    [Val5]-Angiotensin II, human

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • N3228

    Nifedipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥98%
  • T1849

    Temozolomide

    Imidazotetrazine, DNA alkylator.

    ≥98%
  • B030966

    BAY 11-7082

    inhibits inflammatory signaling

    ≥98%
  • F1854

    Fenticonazole Nitrate

    Imidazole; 14-α demethylase inhibitor, potenti...

    ≥98%
  • S0045

    Salbutamol Sulfate

    β2-adrenergic agonist.

    ≥98%
  • I6804

    Irbesartan

    PPARγ agonist, AT1 inhibitor.

    ≥98%
  • T503720

    TMS

    Selective inhibitor of cytochrome P450 1B1 (CYP...

    ≥99%
  • S1606

    Secretin, porcine

    Endogenous peptide hormone, involved in water h...

    ≥95%
  • P8270

    Purvalanol A

    Purine derivative; CDK inhibitor.

    ≥98%
  • T3031

    Thienylbutyl Isothiocyanate

    ITC.

    ≥96%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only