LKT Labs

Biochemicals for Life Science Research

Histatin 5

Histatin 5

Product ID H3273
Cas No. 115966-68-2
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $147.00 In stock
1 mg $262.50 In stock
2.5 mg $525.00 Please Inquire
Bulk Quote

Quicklinks

Description

Histatin 5 is an endogenous antimicrobial peptide (AMP) present in the salivary gland. Histatin 5 exhibits anti-inflammatory, antibacterial, and antifungal activities. In myeloid dendritic cells, histatin 5 binds Poryphyromonas hemagglutinin B, inhibiting production of MIP-1α, MIP-1β, and TNF-α. Histatin binds bacterial DNA, displaying bactericidal activity against gram positive bacteria such as Streptococcus. Additionally, histatin 5 causes ion flux-induced cell death of Candida cells in an ex vivo model of oral candidiasis.

Product Info

Cas No.

115966-68-2
Purity

≥95%
Formula

C133H195N51O33
Formula Wt.

3036.36
Solubility

Soluble in water.
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

H3273 MSDS PDF
Info Sheet

H3273 Info Sheet PDF

References

Borgwardt DS, Martin AD, Van Hemert JR, et al. Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses. Sci Rep. 2014 Jan 29;4:3904. PMID: 24473528.

Huo L, Zhang K, Ling J, et al. Antimicrobial and DNA-binding activities of the peptide fragments of human lactoferrin and histatin 5 against Streptococcus mutans. Arch Oral Biol. 2011 Sep;56(9):869-76. PMID: 21382611.

Peters BM, Zhu J, Fidel PL Jr, et al. Protection of the oral mucosa by salivary histatin-5 against Candida albicans in an ex vivo murine model of oral infection. FEMS Yeast Res. 2010 Aug 1;10(5):597-604. PMID: 20491938.

Jang WS, Bajwa JS, Sun JN, et al. Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans. Mol Microbiol. 2010 Jul;77(2):354-70. PMID: 20487276.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G1646

    Geldanamycin

    HSP90 inhibitor.

    ≥97%
  • I7155

    Isoindigo

    Potential AhR binding agent.

    ≥98%
  • C5655

    α-Conotoxin GI

    Peptide toxin found in Conus snails; nAChR inhi...

    ≥95%
  • L589921

    Loxapine Succinate

    D2 and D4 dopamine receptor inhibitor.

    ≥99%
  • T3357

    Tioconazole

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • A5061

    Ampalex

    Benzylpiperidine; AMPA potentiator.

    ≥98%
  • N5766

    L-(-)-Norepinephrine Bitartrate Monohydrate

    Endogenous hormone and neurotransmitter involve...

    ≥98%
  • M7200

    MS436

    BRD4 inhibitor.

    ≥99%
  • M1744

    Melittin

    Antimicrobial peptide found in Apis mellifera.<...

    ≥95%
  • G1749

    Gemfibrozil

    Fibrate; PPARα agonist, enoyl-CoA reductase in...

    ≥98%
  • A040068

    AB-680

    CD73 inhibitor

    ≥98%
  • V1868

    Veratramine

    Steroidal alkaloid found in Veratrum and Fritil...

    ≥98%
  • A9818

    Azelastine Hydrochloride

    TRPV1 agonist, histamine H1 antagonist.

    ≥98%
  • O938582

    41-Oxo-rapamycin

    Impurity of rapamycin

    ≥95%
  • A0819

    Acetylsalicylic Acid

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • D3429

    Dihydrocytochalasin B

    Mycotoxin derivative; actin polymerization inhi...

    ≥98%
  • V3326

    Virginiamycin S1

    Macrolide antibiotic; peptidyl transferase inhi...

    ≥99%
  • M1875

    S-(N-Methylsulfinylbutylthiocarbamoyl)-glutathione

    Glutathione-sulforaphane conjugate, antioxidant...

    ≥98%
  • N5770

    Norfloxacin Hydrochloride

    First generation fluoroquinolone antibiotic.

    ≥98%
  • V5870

    Vortioxetine

    5-HT1A agonist, 5-HT1B partial agonist, 5-HT3A/...

    ≥99%