LKT Labs

Biochemicals for Life Science Research

Saracatinib

Saracatinib

Product ID S0168
Cas No. 379231-04-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $45.30 In stock
5 mg $67.80 In stock
25 mg $225.40 In stock
Bulk Quote

Quicklinks

Description

Saracatinib is an inhibitor of Src and Abl family kinases that is used for its anticancer chemotherapeutic and immunomodulatory benefits. Saracatinib is currently in clinical trials as a potential treatment for a variety of cancers, including non-small cell lung cancer (NSCLC), pancreatic cancer, gastric cancer, and myeloma. In cellular and animal models, this compound inhibits migration, invasion, and growth of cancer cells. Additionally, saracatinib displays mixed immunomodulatory effects, decreasing T cell cytokine production in one in vitro model and increasing CD8+ memory T cells and production of IFN-γ in another in vitro model.

Product Info

Cas No.

379231-04-6
Purity

≥98%
Formula

C27H32ClN5O5
Formula Wt.

542.03
Chemical Name

N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
IUPAC Name

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine
Synonym

AZD-0530
Appearance

Off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

S0168 MSDS PDF
Info Sheet

S0168 Info Sheet PDF

References

Gangadhar TC, Clark JI, Karrison T, et al. Phase II study of the Src kinase inhibitor saracatinib (AZD0530) in metastatic melanoma. Invest New Drugs. 2013 Jun;31(3):769-73. PMID: 23151808.

Nam HJ, Im SA, Oh DY, et al. Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer. Mol Cancer Ther. 2013 Jan;12(1):16-26. PMID: 23144237.

Cavalloni G, Peraldo-Neia C, Sarotto I, et al. Antitumor activity of Src inhibitor saracatinib (AZD-0530) in preclinical models of biliary tract carcinomas. Mol Cancer Ther. 2012 Jul;11(7):1528-38. PMID: 22452946.

Takai S, Sabzevari H, Farsaci B, et al. Distinct effects of saracatinib on memory CD8+ T cell differentiation. J Immunol. 2012 May 1;188(9):4323-33. PMID: 22450814.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S6018

    Spectinomycin Dihydrochloride Pentahydrate

    Aminocyclitol; protein synthesis inhibitor. &nb...
    ≥603 µg/mg (potency)
  • D1770

    Dermorphin Analog

    Synthetic peptide; dermorphin analog; δOR and ...

    ≥95%
  • A5275

    [Des-Asp1]-Angiotensin I, human

    Peptide, derivative of AT I, cleavage product o...

    ≥95%
  • C0396

    CAY10505

    p110γ PI3K inhibitor.

    ≥98%
  • N1983

    Neuropeptide Y (3-36), human

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • L5751

    Lomerizine Dihydrochloride

    L-type and T-type Ca2+ and TRP antagonist.

    ≥98%
  • L2800

    LH846

    Casein kinase 1α/δ/ε inhibitor.

    ≥98%
  • D5992

    Doxapram Hydrochloride Hydrate

    K+ channel blocker, catecholamine release stimu...

    ≥98%
  • K0040

    Kahweol Stearate

    Diterpene found in coffee beans.

    ≥98%
  • V0245

    Valdecoxib

    NSAID; CB1 agonist, COX-2 inhibitor.

    ≥98%
  • C0271

    Carfilzomib

    Epoxomicin analog; proteasome inhibitor.

    ≥98%
  • M1680

    5-Methoxyindole

    Core structure of melatonin; potential PPARγ a...

    ≥98%
  • N1868

    Neratinib

    EGFR inhibitor.

    ≥98%
  • P6870

    Propofol

    GABA-A agonist, NMDA antagonist, voltage-gated ...

    ≥98%
  • A7668

    Atracurium Besylate

    Non-depolarizing NMJ blocker; AChR antagonist.<...

    ≥95%
  • F4680

    Flutamide

    Non-steroid; AR antagonist.

    ≥98%
  • P5712

    Podophyllotoxin

    Non-alkaloid lignan found in Podophyllum,deriva...

    ≥90%
  • L5750

    Lomeguatrib

    MGMT inhibitor.

    ≥98%
  • T5944

    Tolmetin Sodium

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • V574451

    Volitinib

    c-Met inhibitor.

    ≥98%