LKT Labs

Biochemicals for Life Science Research

Saracatinib

Saracatinib

Product ID S0168
Cas No. 379231-04-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $45.00 In stock
5 mg $68.00 In stock
25 mg $225.00 In stock
Bulk Quote

Quicklinks

Description

Saracatinib is an inhibitor of Src and Abl family kinases that is used for its anticancer chemotherapeutic and immunomodulatory benefits. Saracatinib is currently in clinical trials as a potential treatment for a variety of cancers, including non-small cell lung cancer (NSCLC), pancreatic cancer, gastric cancer, and myeloma. In cellular and animal models, this compound inhibits migration, invasion, and growth of cancer cells. Additionally, saracatinib displays mixed immunomodulatory effects, decreasing T cell cytokine production in one in vitro model and increasing CD8+ memory T cells and production of IFN-γ in another in vitro model.

Product Info

Cas No.

379231-04-6
Purity

≥98%
Formula

C27H32ClN5O5
Formula Wt.

542.03
Chemical Name

N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
IUPAC Name

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine
Synonym

AZD-0530
Appearance

Off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

S0168 MSDS PDF
Info Sheet

S0168 Info Sheet PDF

References

Gangadhar TC, Clark JI, Karrison T, et al. Phase II study of the Src kinase inhibitor saracatinib (AZD0530) in metastatic melanoma. Invest New Drugs. 2013 Jun;31(3):769-73. PMID: 23151808.

Nam HJ, Im SA, Oh DY, et al. Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer. Mol Cancer Ther. 2013 Jan;12(1):16-26. PMID: 23144237.

Cavalloni G, Peraldo-Neia C, Sarotto I, et al. Antitumor activity of Src inhibitor saracatinib (AZD-0530) in preclinical models of biliary tract carcinomas. Mol Cancer Ther. 2012 Jul;11(7):1528-38. PMID: 22452946.

Takai S, Sabzevari H, Farsaci B, et al. Distinct effects of saracatinib on memory CD8+ T cell differentiation. J Immunol. 2012 May 1;188(9):4323-33. PMID: 22450814.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T5869

    Torcetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • C0396

    CAY10505

    p110γ PI3K inhibitor.

    ≥98%
  • A4924

    AMG-208

    c-MET and Ron inhibitor.

    ≥98%
  • T0116

    2″,3″-Dihydrocephalomannine

    Cephalomannine derivative found in Taxus; poten...

    ≥96%
  • L3561

    D,L-α-Lipoic Acid

    Endogenous organosulfur also found in meat and ...

    ≥99%
  • T1673

    Terlipressin Acetate

    Synthetic peptide, vasopressin analog; AVPR1 ag...

    ≥95%
  • F6803

    FRAX486

    PAK inhibitor.Smo inhibitor.

    ≥98%
  • E4668

    ELR-510444

    Microtubule polymerization inhibitor.

    ≥98%
  • B0245

    Balicatib

    Cathepsin K inhibitor.

    ≥98%
  • S6232

    Spiramycin

    Macrolide; protein synthesis inhibitor. ≥3900...

    ≥3900 IU/mg
  • G0106

    Gabapentin

    GABA analog; GABA potentiator, adenosine A1 ago...

    ≥98%
  • L0528

    LBH-589

    HDAC1/2/3/11 inhibitor.

    ≥98%
  • B8676

    BVT-2733

    11β-HSD1 inhibitor.

    ≥98%
  • T5605

    Tobramycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • H6225

    HPGDS-inhibitor-1

    HPGDS inhibitor.

    ≥98%
  • M1778

    S-(+)-α−Methylbenzyl Isothiocyanate

    ITC, used as chiral agent.

    ≥98%
  • V182705

    Verubecestat

    BACE1 inhibitor

    ≥98%
  • A2044

    Aflatoxin B1

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • D0032

    Daidzein

    Phytoestrogen, isoflavone found in various plan...

    ≥97%
  • K0276

    Katacalcin

    Peptide found in crustaceans; PKA activator.

    ≥95%