Lycorine Hydrochloride

Name: Lycorine Hydrochloride
SKU: L9610
Availability: InStock

Product ID L9610

Cas No. 2188-68-3

Purity ≥98%

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Description

Lycorine is an alkaloid found in plants in the Amaryllidaceae family; it exhibits antifungal, anti-parasitic, and anticancer activities. Lycorine inhibits protein synthesis by preventing amino acid incorporation info proteins, potentially through the inhibition of peptidyltransferases. Lycorine inhibits the growth of many fungi, including Fusarium. Additionally, lycorine induces cell cycle arrest and cell death in Trichomonas. This compound also induces G0/G1 phase cell cycle arrest, inhibits activity of histone deacetylases (HDACs), upregulates expression of p53 and p21, downregulates expression of cyclin D1 and CDK4, and inhibits growth in chromic myelogenous leukemia (CML) cells.

Product Info

Cas No.	2188-68-3
Purity	≥98%
Formula	C₁₆H₁₇NO₄ • HCl
Formula Wt.	323.77
IUPAC Name	(1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol;hydrochloride
Synonym	Lycorine HCl
Solubility	Soluble in water (>15 mg/ml), DMSO, and ethanol
Appearance	White to off white powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	L9610 MSDS PDF
Info Sheet	L9610 Info Sheet PDF

References

Shen JW, Ruan Y, Ren W, et al. Lycorine: a potential broad-spectrum agent against crop pathogenic fungi. J Microbiol Biotechnol. 2014 Mar 28;24(3):354-8. PMID: 24346469.

Li L, Dai HJ, Ye M, et al. Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition. Cancer Cell Int. 2012 Nov 23;12(1):49. PMID: 23176676.

Giordani RB, Vieira Pde B, Weizenmann M, et al. Lycorine induces cell death in the amitochondriate parasite, Trichomonas vaginalis, via an alternative non-apoptotic death pathway. Phytochemistry. 2011 May;72(7):645-50. PMID: 21324496.

Yui S, Mikami M, Mimaki Y, et al. Inhibition effect of Amaryllidaceae alkaloids, lycorine and lycoricidinol on macrophage TNF-alpha production. Yakugaku Zasshi. 2001 Feb;121(2):167-71. PMID: 11218731.

Kukhanova M, Victorova L, Krayevsky A. Peptidyltransferase center of ribosomes. On the mechanism of action of alkaloid lycorine. FEBS Lett. 1983 Aug 22;160(1-2):129-33. PMID: 6350039.

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Lycorine Hydrochloride

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Description

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