LKT Labs

Biochemicals for Life Science Research

Dexamethasone

Dexamethasone

Product ID D1693
Cas No. 50-02-2
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $86.50 In stock
500 mg $198.80 In stock
1 g $264.40 In stock
Bulk Quote

Quicklinks

Description

Dexamethasone is a glucocorticoid that exhibits anti-inflammatory and immunosuppressive activities with minimal mineralocorticoid effect. Under inflammatory conditions, dexamethasone decreases secretion of TNF, IL-6, and IL-1β, inhibiting migration and maturation of macrophages. Dexamethasone may also display anti-asthma benefit as well, through the upregulation of PTEN expression. Additionally, dexamethasone is often used in combination with other chemotherapies in the treatment of multiple myeloma.

Product Info

Cas No.

50-02-2
Purity

≥99%
Formula

C22H29FO5
Formula Wt.

392.46
Chemical Name

(11β,16α)-9-Fluoro-11,17,21-trihydro-16-methyl- pregna-1,4-diene-3,20-dione
IUPAC Name

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11, 17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15, 16-octahydrocyclopenta[a]phenanthren-3-one
Synonym

Decadron, Maxidex
Melting Point

223-233°C

Solubility

Soluble in DMF (25 mg/mL) and DMSO (25 mg/mL). Sparingly soluble in ethanol. Insoluble in water.
Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

D1693 MSDS PDF
Info Sheet

D1693 Info Sheet PDF

References

Bartneck M, Peters FM, Warzecha KT, et al. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages. Nanomedicine. 2014 Mar 7. [Epub ahead of print]. PMID: 24607939.

Ni Z, Tang J, Cai Z, et al. A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression. Respir Res. 2011 Apr 14;12:47. PMID: 21489309.

Morgan G. Future drug developments in multiple myeloma: an overview of novel lenalidomide-based combination therapies. Blood Rev. 2010 Nov;24 Suppl 1:S27-32. PMID: 21126634.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B6807

    [Des-Arg9]-Bradykinin

    Natriuretic, vasodilatory peptide, bradykinin a...

    ≥95%
  • T1298

    TDZD-8

    GSK-3β inhibitor.

    ≥98%
  • F0150

    Famotidine

    Histamine H2 antagonist, GSK-3β inhibitor.

    ≥98%
  • M5753

    Monensin Sodium

    Polyether ionophore, autophagy inhibitor.

    ≥98%
  • G2869

    Ghrelin, rat

    Endogenous peptide hormone, involved in feeding...

    ≥95%
  • R2513

    RGDS

    Tetrapeptide, binds cell surface integrins.

    ≥95%
  • E0001

    E64

    Cysteine protease inhibitor.

    ≥99%
  • C2900

    CH5424802

    ALK inhibitor.

    ≥99%
  • X4424

    XL-765

    PI3K and mTOR inhibitor.

    ≥98%
  • G1975

    Gestrinone

    Synthetic steroid hormone; AR agonist, ER and P...

    ≥98%
  • O1200

    Odanacatib

    Cathepsin K inhibitor.

    ≥99%
  • F4782

    Fludarabine Phosphate

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • T1006

    10-Acetoacetyl Paclitaxel

    Synthesis impurity

    ≥95%
  • P3592

    Pixantrone Dimaleate

    Aza-anthracenedione, DNA intercalator; topoisom...

    ≥98%
  • Z5744

    Zoledronic Acid Hydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%
  • P600006

    RP-6306

    PKMYT1 inhibitor

    ≥98%
  • I6068

    Ipriflavone

    Synthetic isoflavone.

    ≥98%
  • W5727

    Wogonoside

    Flavonoid glycoside found in Scutellaria.

    ≥98%
  • P2858

    4-α-Phorbol-12-myristate-13-acetate

    Negative control for PKC activation.

    ≥98%
  • G4598

    Glycyrrhizic Acid Ammonium Hydrate

    Triterpene glycoside found in Glycyrrhiza; 11β...

    ≥93%