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cGAMP is a cyclic dinucleotide that functions as an endogenous second messenger that detects cytosolic DNA and induces STING-dependent interferon type 1 responses. cGAMP exhibits immunostimulatory activity and acts as an adjuvant. This compound enhances adaptive immune responses by increasing antigen-specific IgG levels in vivo.
| Cas No. | 2407516-83-8, 849214-04-6 (free acid) |
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| Purity | ≥98% |
| Formula | C20H24N10O13P2・Na2 |
| Formula Wt. | 718.37 |
| Chemical Name | 3',3'-cGAMP disodium |
| IUPAC Name | disodium;2-amino-9-[(1S,6R,8R,9R,10S,15R,17R,18R)-17-(6-aminopurin-9-yl)-9,18-dihydroxy-3,12-dioxido-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3λ5,12λ5-diphosphatricyclo[13.3.0.06,10]octadecan-8-yl]-1H-purin-6-one |
| Synonym | cyclic (adenosine monophosphate-guanosine monophosphate), cyclic GMP-AMP, c-(GpAp), 3',3'-cGAMP |
| Solubility | Soluble in water. |
| Appearance | Crystalline solid. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ma F, Li B, Liu SY, et al. Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS. J Immunol. 2015 Feb 15;194(4):1545-54. PMID: 25609843.
Škrnjug I, Guzmán CA, Rueckert C. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150. Erratum in: PLoS One. 2015;10(3):e0123605. Ruecker, Christine [corrected to Rueckert, Christine]. PMID: 25295996.
Wu J, Sun L, Chen X, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30. PMID: 23258412.