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Thalidomide has previously been clinically used as a sedative but was found to induce birth defects in pregnant females. Recently, thalidomide exhibits anticancer chemotherapeutic potential in the treatment of multiple myeloma. Additionally, thalidomide displays anti-inflammatory and immunomodulatory activities, improving TNBS-induced colitis in animal models by increasing expression of IL-10 and decreasing expression of TNF-α and IL-1β.
| Cas No. | 50-35-1 |
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| Purity | ≥98% |
| Formula | C13H10N2O4 |
| Formula Wt. | 258.23 |
| Chemical Name | (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| IUPAC Name | 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| Synonym | 1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline, Actimid, Calmore, Distaval, Sedimide,Telagan |
| Melting Point | 269-271°C |
| Solubility | Insoluble in water and ethanol. Soluble in DMSO (56 mg/mL). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Lien IC, Horng LY, Hsu PL, et al. Internal ribosome entry site of bFGF is the target of thalidomide for IMiDs development in multiple myeloma. Genes Cancer. 2014 Mar;5(3-4):127-41. PMID: 25053990.
Xu J, Zheng C, Huang Y, et al. Efficacy of thalidomide on trinitrobenzene sulfonate-induced colitis in young rats and its mechanism. Chin Med J (Engl). 2014;127(12):2368-75. PMID: 24931258.
Zhou S, Wang F, Hsieh TC, et al. Thalidomide-a notorious sedative to a wonder anticancer drug. Curr Med Chem. 2013;20(33):4102-8. PMID: 23931282.