LKT Labs

Biochemicals for Life Science Research

Synephrine

Synephrine

Product ID S9753
Cas No. 94-07-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $45.80 In stock
5 g $64.50 In stock
10 g $107.30 In stock
25 g $214.60 In stock
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Description

Synephrine is an endogenous alkaloid that can also be found in citrus fruits, Evodia, and Zanthoxylum. Synephrine exhibits vasoconstrictive, anti-inflammatory, antibacterial, and gastrointestinal motility modulating activities. Synephrine acts as a positive inotrope, activating adrenergic receptors (displaying partial selectivity for α-adrenergic receptors), TAAR-1 receptors, and 5-HT receptors. Synephrine decreases levels of ROS, activity of myeloperoxidase, infiltration of inflammatory cells, and expression of TNF-α and IL-6 in the lungs of animal models of lung injury and inflammation. Additionally, synephrine inhibits gastrointestinal motility and slows gastric emptying.

Product Info

Cas No.

94-07-5
Purity

≥98%
Formula

C9H13NO2
Formula Wt.

167.21
Chemical Name

4-Hydroxy-α-[(methylamino)methyl]benzenemethanol
IUPAC Name

4-[1-hydroxy-2-(methylamino)ethyl]phenol
Synonym

Analeptin, Ethaphene, Oxedrine, Parasympatol, Simpalon, Synerphrin, Synthenate
Melting Point

184-185°C
Solubility

Soluble in water (400 mg/mL).
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

S9753 MSDS PDF
Info Sheet

S9753 Info Sheet PDF

References

Wu Q, Li R, Soromou LW, et al. p-Synephrine suppresses lipopolysaccharide-induced acute lung injury by inhibition of the NF-κB signaling pathway. Inflamm Res. 2014 Jun;63(6):429-39. PMID: 24487736.

Ozçelik B, Kartal M, Orhan I. Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids. Pharm Biol. 2011 Apr;49(4):396-402. PMID: 21391841.

Fang YS, Shan DM, Liu JW, et al. Effect of constituents from Fructus Aurantii Immaturus and Radix Paeoniae Alba on gastrointestinal movement. Planta Med. 2009 Jan;75(1):24-31. PMID: 19016407.

Endoh M, Schümann HJ, Krappitz N, et al. alpha-Adrenoceptors mediating positive inotropic effects on the ventricular myocardium: some aspects of structure-activity relationship of sympathomimetic amines. Jpn J Pharmacol. 1976 Apr;26(2):179-90. PMID: 7694.

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