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Atrial natriuretic peptide (ANP) is a cardiomodulatory peptide that binds the natriuretic peptide receptor type A (NPR-A), increasing levels of cGMP and activating cGMP-dependent kinases. ANP exhibits vasodilatory/hypotensive, diuretic, and natriuretic activities, increasing perfusion and decreasing blood pressure in several models. ANP may also exhibit anticancer benefit, targeting the Ras-MEK-ERK signaling pathway.
| Cas No. | 91917-63-4 |
|---|---|
| Purity | ≥95% |
| Formula | C127H203N45O39S3 |
| Formula Wt. | 3080.46 |
| Synonym | Atrial Natriuretic Peptide human, Urodilatin, hANF, alpha ANF (1-28) |
| Solubility | Soluble in 5% acetic acid. |
| Appearance | White to off-white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Vesely DL. New anticancer agents: hormones made within the heart. Anticancer Res. 2012 Jul;32(7):2515-21. PMID: 22753708.
Woodard GE, Rosado JA. Natriuretic peptides in vascular physiology and pathology. Int Rev Cell Mol Biol. 2008;268:59-93. PMID: 18703404.